384 
Anthemis  Cotula. 
Am.  Jour.  Pharm. 
Aug.,  1891. 
tion  of  resin,  agitated  with  ether  or  chloroform,  which  left  a 
slightly  acid  residue  on  evaporation. 
Absolute  alcohol  extracted  from  the  drug  218  per  cent,  of  resin, 
with  traces  of  an  organic  acid  and  traces  of  a  bitter  principle.  The 
solution  of  the  alcohol  extract  dissolved  in  alcohol,  poured  into 
water  acidified  with  dilute  hydrochloric  acid  and  then  made  alkaline 
yielded  on  agitation  with  chloroform  and  evaporation  of  this  solvent 
a  substance  which,  when  dissolved  in  dilute  acid,  gave  precipitates 
with  alkaloidal  reagents,  similar  indications  were  gotten  from  resi- 
dues of  agitations  of  ether  and  chloroform  with  the  acidified  aque- 
ous solution  of  the  alcohol  extract. 
Water  extracted  from  the  drug  17-78  per  cent,  of  solid  matter, 
3-20  per  cent,  of  which  was  ash,  leaving  14-58  per  cent,  of 
organic  matter  in  the  aqueous  extract.  This  contained  3-20  per 
cent,  of  mucilage,  4-32  per  cent,  of  glucose  and  3-62  per  cent,  of 
unreducible  sugar,  leaving  3-44  per  cent,  of  undetermined  extractive. 
The  drug  then  yielded  7-74  per  cent,  to  dilute  soda  solution.  2  96 
per  cent,  of  this  consisted  of  albuminoids ;  the  remainder  of  the 
alkaline  extract  was  undetermined.  Dilute  hydrochloric  acid  then 
extracted  from  the  drug  3-60  per  cent.,  of  which  1-28  per  cent,  was 
found  to  be  calcium  oxalate  and  1*13  per  cent,  pararabin. 
The  lignin  was  found  to  equal  5-43  per  cent.,  and  the  amount  of 
cellulose  was  not  determined. 
A  convenient  quantity  of  the  drug  was  distilled  with  a  one  per 
cent,  aqueous  solution  of  sulphuric  acid.  The  distillate  was  neu- 
tralized with  calcium  carbonate  and  filtered,  the  filtrate  was  concen- 
trated to  a  small  bulk  and  a  portion  warmed  with  sulphuric  acid, 
when  a  strong  odor  of  valerianic  acid  was  evolved  ;  to  another  por- 
tion sulphuric  acid  and  alcohol  were  added  when  the  odor  of  valeri- 
anic ether  became  very  apparent  on  warming. 
A  quantity  of  the  drug  was  distilled  with  milk  of  lime,  the  dis- 
tillate, which  was  alkaline,  was  acidified  with  hydrochloric  acid  and 
agitated  with  ether  which  removed  volatile  oil.  The  distillate  was 
then  made  alkaline  and  agitated  successively  with  ether  and  chloro- 
form. A  slight  excess  of  hydrochloric  acid  was  added  to  each  and 
the  solvent  allowed  to  evaporate  spontaneously.  The  two  residues 
appeared  to  be  identical,  so  they  were  mixed,  dissolved  in  ether  and 
set  aside  to  evaporate  spontaneously  which  left  the  alkaloid  in 
a  pure  state.    This  alkaloid  was  a  reddish  brown  volatile  liquid, 
