Am.  Jour.  Pharm. 
Aug.,  1891. 
Cannabis  hidica. 
389 
parent  varnish-like  substance.  It  had  a  strong,  peculiar  odor, 
resembling  that  of  conine,  still  stronger  on  the  application  of  heat, 
was  soluble  in  ether,  chloroform,  alcohol,  and  acidulated  water,  but 
only  slightly  so  in  water,  was  alkaline  to  test  paper  and  capable  of 
neutralizing  acids.  When  dissolved  in  very  dilute  H2S04  (1  gtt.  in 
5  cc.)  it  gave  a  clear  yellow  solution  and  the  following  reactions : 
With  Mayer's  reagent,  abundant  white  precipitate. 
KI  -f  1  -j-  H20,  abundant  brown  precipitate. 
Phosphomolybdate  of  Soda,  abundant  white  precipitate. 
Solution  Picric  Acid,  abundant  yellow  precipitate. 
Solution  K2C207,  yellowish  brown  precipitate. 
Solution  NH4OH,  yellowish  green  precipitate. 
Solution  NaOH,  yellowish  green  precipitate. 
Solution  KOH,  yellowish  green  precipitate. 
Solution  KI,  yellowish  precipitate. 
Solution  Tannic  Acid,  yellov/ish  brown  precipitate. 
The  second  method  was  upon  a  somewhat  larger  scale  and  by  a 
different  process*.  In  this  method  one  kilo  of  the  drug  was  rendered  to 
a  number  40  powder,  mixed  with  3,000  cc.  of  95  per  cent,  alcohol, 
and  macerated  for  13  days,  occasionally  agitated ;  now  transferred 
to  a  cylindrical  percolator,  allowed  to  drain  well  and  the  drug 
exhausted  with  I, OOO  cc.  of  95  per  cent,  alcohol.  The  alcoholic 
fluid  extract  was  made  slightly  acid  with  H2S04,  allowed  to  stand 
for  3  hours,  the  alcohol  driven  off  on  a  water  bath  at  a  temperature 
not  exceeding  890  C  and  small  quantities  of  acidulated  water  added 
from  time  to  time.  The  remaining  solution  with  resin  was  trans- 
ferred to  a  filter,  which  retained  the  resin,  and  the  filter  washed 
with  50  cc.  of  acidulated  water.  The  filtrate  of  a  clear  and 
yellowish-brown  color,  was  transferred  to  a  separatory  funnel,  1 50  cc. 
of  ether  were  added,  then  rendered  alkaline  with  NaOH  (5  per  cent.) 
allowed  to  stand  for  one  hour,  occasionally  agitated,  ethereal  solu- 
tion drawn  off,  the  operation  repeated  with  100  cc.  of  ether,  and 
the  water  solution  rejected.  The  united  ethereal  solutions  were 
transferred  to  a  separatory  funnel,  and  100  cc  of  dilute  H2S04 
added  ;  the  mixture  was  allowed  to  stand  for  one-half  hour,  occa- 
sionally agitated,  the  water  solution  drawn  off,  the  operation 
repeated  with  50  cc.  of  acidulated  water,  and  the  ethereal  solution 
rejected.  The  water  solutions  were  united,  transferred  to  a  separa- 
tory funnel,  75  cc  of  ether  were  added,  made  alkaline  with  NaOH, 
