4-02  Abstracts  from  the  French  Journals.   {Am iugr;i?fiarm' 
of  potassium.  It  acts  as  a  tonic,  diuretic  and,  at  first,  as  an  emetic. 
Cholagogue  properties  are  attributed  to  it  by  the  natives.  Dr. 
Heckel  found  that  it  sometimes  gave  rise  to  a  bilious  diarrhoea. 
Quinine  for  Hypodermic  Use. — At  the  meeting  of  May  6th,  of 
the  Paris  Society  of  Pharmacy,  M.  Vigier  said  that  five  per  cent, 
solutions  of  lactate  of  quinine  could  not  be  made  after  this  com- 
pound has  once  been  dried.  They  should  be  made  extemporane- 
ously for  this  purpose.  M.  Barille  stated  that  M.  Laveran  no  longer 
used  lactate  and  hydrochlorate  of  quinine  extemporaneously,  but, 
taking  advantage  of  the  power  of  antipyrine  in  favoring  the  solu- 
bility of  quinine,  he  used  the  following  formula  :  Hydrochlorate  of 
quinine,  I  gm.;  antipyrine,  50  cgm.;  water,  2  gm.  The  solutions 
are  not  painful  to  patients. 
Valerianate  of  Antipyrine  and  Quinine. — M.  E.  Sochaczewski 
(Bull.  Comm.,  June)  gives  the  following  as  the  best  method  of 
preparation  :  Dissolve  10  gm.  of  valerianate  of  quinine  in  a  sufficient 
quantity  of  90  per  cent,  alcohol  to  give  a  thoroughly  saturated  solu- 
tion. Dissolve  10  gm.  of  antipyrine  in  the  smallest  possible  quantity 
of  distilled  water.  Mix  the  solutions  in  a  crystallizing  dish  and 
apply  heat,  being  careful  that  it  does  not  go  beyond  1220.  The 
crystals  form  and  no  sub-product  is  obtained.  Some  of  the  crystals 
measure  6  centimetres  in  length. 
Naphthol-Antipyrine. — M.  G.  Patein  (Repert.  de  Phar.,  June  10) 
has  made  this  combination  with  a  and  j3  naphthol,the  former  being 
liquid  and  the  latter  crystallized.  The  preparation  with  /?  naphthol  is 
made  by  dissolving  150  gm.  of  that  substance  in  90  per  cent,  alcohol, 
and  pouring  slowly  into  it,  while  stirring,  a  solution  of  190  gm.  of 
antipyrine  in  the  smallest  possible  amount  of  water.  A  viscous  mass 
forms  in  a  few  minutes.  This  must  be  vigorously  stirred  for  4  or  5 
minutes,  when  the  liquid  will  become  perfectly  clear.  Pure,  fine 
crystals  of  ft  naphthol-antipyrine  are  now  deposited.  By  taking 
these  up  in  warm  60  per  cent,  alcohol,  large,  colorless  crystals  are 
obtained.  These  melt  at  82-830  C.  [i79°6-i8i°-4  F.]  ;  they  are 
soluble  in  alcohol  and  ether.  By  the  addition  of  cold  water  the 
naphthol  precipitates  and  the  antipyrine  remains  in  solution.  De- 
composition is  prevented  by  making  a  solution  as  follows :  ft  naph- 
thol-antipyrine, 1  gm. ;  alcohol  of  90  per  cent.,  25  gm.;  distilled  water, 
40  gm. 
Coronillin  :    A  Characteristic  Reaction. — As  described  by 
