408  Gleanings  from  the  German  Journals.  {AmAug.!i89iarm' 
drops  of  -f-^  iodine  solution;  there  may  be  produced'at  this  stage  a 
dark  turbidity  due  to  nitrogen  iodide  which  will  disappear  upon 
agitation  or  warming  (if  not  too  little  acetone  is  present)  and  show 
the  yellowish  turbidity  due  to  iodoform  ;  more  iodine  solution  can 
then  be  added  until  the  nitrogen  iodide  ceases  to  disappear  ;  and  this 
accomplished  by  the  cautious  addition  of  a  dilute  solution  of  sodium 
thiosulphate,  all  of  the  acetone  is  made  to  react  with  the  produc- 
tion of  iodoform.  The  odor  of  the  latter  is  not  affected  by  the 
presence  of  the  ammonia.  The  reaction  is  quite  delicate,  I  part 
acetone  in  5,000  parts  water  giving  the  precipitate  in  a  few 
minutes;  the  test  is  considered  a  good  one  for  the  detection  of 
acetone  in  urine.  It  is  thought  that  all  bodies  containing  the  group 
CH3.CO  —  will  give  the  reaction. — Prof.  A.  Schwicker,  Chemiker 
Ztg.,  1891,  914. 
Test  for  guaiacol. — The  addition  of  concentrated  sulphuric  acid 
and  a  minute  quantity  of  acetone  to  guaiacol  or  its  compounds 
(benzosol,  etc.)  produces  a  beautiful  cherry-red  or  purplish-red 
coloration  ;  the  addition  of  two  volumes  of  chloroform  to  the  test 
and  agitation  makes  the  color  more  pronounced. — Dr.  J.  Bongartz, 
Pharm.  Ztg.,  1891,  370. 
Salicyl-bromanilide ',  also  called  antznervine,  claimed  to  be  a  combi- 
nation of  salicylanilide  and  bromacetanilide  (Am.  Journ.  Pharm. 
1 891,  345)  has  been  examined  at  various  times  by  Dr.  Ritsert  and 
always  found  to  be  composed  as  follows  :  25  parts  ammonium 
bromide,  25  parts  salicylic  acid  and  50  parts  acetanilide.  An 
interesting  point  was  brought  out  during  the  examination  :  The 
mixture  melted  between  80  and  900  C;  after  removing  the  salicylic 
acid  and  acetanilide  with  chloroform  and  evaporating,  the  residue 
was  found  to  melt  at  82-840  C. ;  mixtures  made  of  salicylic  acid  and 
acetanilide  in  varying  proportions  always  melted  between  80  and 
900.  Another  interesting  observation  was  that  acetanilide  crystal- 
lized from  petroleum-ether  in  needles. — Pharm.  Ztg.,  1891,  393. 
Dermatol. — B.  Fischer  publishes  the  following  method  of  prepara- 
tion, as  it  is  stated  that  the  process  by  which  it  is  made  by  Meister, 
Lucius  and  Bruning  is  to  be  patented:  15  parts  bismuth  subnitrate 
are  dissolved  in  30  parts  glacial  acetic  acid,  200-250  parts  water 
added  and  filtered,  to  this  solution  is  added,  with  constant  stirring  a 
warm  solution  of  5  parts  gallic  acid  in  200-250  parts  water.  The 
precipitate  is  first  washed  by  decantation,  then  on  a  filter  until  the 
