Am.Jour.Pharm.j       Incompatibilities  of  Antipyrin.  147 
March,  1890. 
consideration  any  statements  as  to  the  chemical  nature  of  narceine, 
if  they  are  not  based  upon  experiments  with  chemically  pure 
narceine. 
The  extremely  contradictory  results  which  I  have  myself  obtained 
through  a  series  of  years  with  the  commercial  narceine  formerly 
accepted  as  pure,  was  the  occasion  of  my  taking  part  in  the  settle- 
ment of  the  chemical  properties  of  chemically  pure  narceine,  and  in 
this  sense  I  hoped  to  interest  chemists  by  my  small  communication. 
In  conclusion,  I  would  take  this  opportunity  to  mention  that  I 
have  succeeded  in  obtaining  two  of  the  rarest  opiuiru  alkaloids, 
namely,  laudanine  and  protopine.  I  found  their  properties  to  corre- 
spond essentially  with  the  statements  made  by  Hesse  at  the  time 
he  discovered  them.  Laudanine,  especially,  on  account  of  its  analogy 
to  morphine,  appears  to  be  of  great  interest.  It  is  soluble  in  caustic 
soda  solution  and  can  be  converted  by  methylation  into  a  new  base, 
which  chemically  resembles  codeine. — Phar.  Jour,  and  Trans., 
Dec.  21,  1889,  p.  482. 
SOME  INCOMPATIBILITIES  OF  ANTIPYRIN. 
If  liquid  extract  of  cinchona  be  added  to  a  solution  of  antipyrin 
in  distilled  water,  a  dense  reddish  brown  precipitate  is  formed, 
which  contains  tannic  acid  and  antipyrin.  The  greater  part 
of  this  precipitate  dissolves  on  the  addition  of  dilute  sulphuric 
acid,  the  insoluble  portion  being  probably  the  coloring  matter 
of  the  bark,  for  if  a  solution  of  tannic  acid  be  used  instead 
of  the  liquid  extract  of  cinchona  as  a  precipitating  agent,  a  preci- 
pitate forms,  which  entirely  and  easily  dissolves  on  the  addition  of 
the  dilute  sulphuric  acid.  It  follows,  therefore,  that  decoctions,  infu- 
sions, and  tinctures  containing  tannic  acid  should  act  in  the  same 
manner.  The  effect,,  however,  produced  by  these  preparations  is 
very  small  compared  with  the  liquid  extract  of  cinchona.  Antipyrin 
is  not  precipitated  by  solutions  of  the  alkaloids  quinine,  cinchonine^ 
or  cinchonidine.  Therefore,  it  can  be  prescribed  in  a  mixture  con- 
taining sulphate  of  quinine  and  dilute  sulphuric  acid.  Whenstrong 
solutions  of  chloral  hydrate  and  antipyrin  are  mixed,  a  white  pre- 
cipitate is  formed,  which  soon  becomes  resolved  into  globules  of 
oily-looking  liquid,  which  sink  to  the  bottom  in  a  distinct  layer. 
This  layer  in  the  course  of  some  hours  changes  into  a  crystalline 
