3 -'8 
Marj'iibiu  m  Vu Igare. 
j  Am.  Jour.  Pharrn. 
I       July,  1890. 
The  fat  was  soluble  in  hot  95  per  cent,  alcohol,  and  melted  at  460 
C.  The  wax  was  insoluble  in  this  solvent,  but  dissolved  in  carbon 
bisulphide.  The  crystalline  principle  was  extracted  from  the  drug 
with  stronger  ether,  and  purified  by  repeated  crystallization  from 
hot  95  per  cent,  alcohol,  with  one  or  more  treatments  with  animal 
charcoal.  The  crystals  were  insoluble  in  water  and  in  solution  of 
potassium  hydrate,  very  sparingly  soluble  in  boiling  water  and  in 
cold  alcohol.  Soluble  in  hot  95  per  cent,  alcohol,  also  in  ether  and 
chloroform.  They  melted  at  1 5 2°  to  1 5 3 0  C.  They  were  at  first 
tasteless,  but  developed,  when  held  on  the  tongue,  a  decided  bitter- 
ness.   The  alcoholic  solution  was  very  bitter. 
Sulphuric  or  nitric  acid  gave  a  dark  brown  color,  hydrochloric 
acid  produced  no  change  and  ferric  chloride  produced  no  change. 
Tiiis  principle  reduced  Fehling's  solution  by  a  boiling  water-bath, 
without  first  treating  with  an  acid.  On  boiling  it  first  with  acidu- 
lated water  a  peculiar  aromatic  odor  was  developed,  then  on  heating 
with  Fehling's  solution  an  abundant  precipitate  of  cuprous  oxide 
was  produced,  thus  showing  it  to  be  an  easily  decomposed  gluco- 
side. 
A  small  quantity  of  a  bitter  principle  was  extracted  from  the 
drug  by  absolute  alcohol,  along  with  the  resin.  This  appeared  to 
be  different  from  the  previous  one  extracted  by  ether,  and  for  the 
purpose  of  further  investigation,  a  larger  quantity  of  the  drug  was 
exhausted  with  ether,  the  solvent  recovered  and  the  residue  treated 
with  petroleum  ether  to  remove  fat  and  wax.  The  remaining  portion 
was  dissolved  in  hot  alcohol,  treated  with  animal  charcoal  and  crys- 
tallized. The  crystals  were  purified  by  repeated  crystallization  and 
treatment  with  animal  charcoal.    Melting  point,  1 5 2°  to  1530  C. 
The  average  of  two  combustion  was  : 
Found 
c,  .  .  .  .    70-25 
H,   8-42 
O,   21-33 
100*00  IOO'OO 
Three  samples  of  crystals,  presented  with  a  thesis  of  last  year  by 
Frederick  G.  Hertel,  Ph.G.  (American  Journal  of  Pharmacy,  1890, 
p.  273)  and  obtained  by  him  from  the  fluid  extract,  were  also  exam- 
ined.   O.ie  of  these,  which  he  had  crystallized  from  cold  alcohol, 
Calculated  for. 
(C4oH5809.) 
70-38 
8-50 
21-12 
