334  Observations  on  Some  Fluid  Extracts.  {AmjJu°1^'l8Piarm 
No.  i  was  kept  on  hand  for  six  months,  when  it  had  deposited  a 
slight  precipitate  which,  after  being  collected  on  a  weighed  filter, 
was  found  to  amount  to  1-25  gm.    The  results  tabulated  are  as 
follows : 
U.  S.  P.  PROCESS.  REPERCOLATION. 
No  i.  No.  2.  No.  3.  No  4.  No.  5.  No.  6. 
Percolates.                          Per  Cent.    Per  Cent.  Per  Cent.  Per  Cent.  Per  Cent.  Per  Cent. 
First  portion,  2075  18*10  2140  22  So  22-20  18*60 
Second  portion,                      5-50  6*25  6  30  5-90  570  6*05 
Third  portion,                         195  2  60  210  215  2*15  2*20 
Fourth  portion,                         -95  1*15  "85  1-30  i'20  125 
Fifth  portion,                           -35  '65  -45  -50  -45  70 
Total  extractive,  .  .  .    29-50       28-75       3110       3275       3170  28-80 
Extraction  Grindelia  Fluidum. — Aiming  at  preparing  this  fluid 
extract  so  as  to  mix  with  water  without  precipitating,  W.  H.  Kun- 
kle,  Ph.G  ,  used  first  the  pharmacopceial  menstruum,  alcohol  3  p., 
water  1  p.;  secondly,  diluted  alcohol, 'and  thirdly,  diluted  alcohol 
rendered  alkaline  by  5  gm.  soda  solution  for  100  gm.  of  powdered 
grindelia.  These  preparations  were  precipitated  by  water.  But  the 
fluid  extract  remained  clear  on  dilution,  when  prepared  by  exhaust- 
ing the  powder  with  water  containing,  for  100  gm.  of  powder,  2  gm. 
of  borax;  reserving  the  first  60  cc.  of  the  percolate;  evaporating  the 
remainder  to  a  soft  extract;  dissolving  this  in  the  reserved  liquid; 
adding  water  to  make  75  cc,  and  then  mixing  with  25  cc.  of  alcohol. 
A  precipitate  is  produced  which  appears  to  consist  mainly  of  borax 
and  gummy  matter,  and  after  filtering,  a  handsome  preparation  was 
yielded  which  was  miscible  with  water  in  all  proportions  without 
causing  a  precipitate.  No  observations  are  recorded  as  to  the 
medicinal  effects  of  this  borated  fluid  extract ;  but  reference  is  made 
to  the  suggestion  of  Dr.  W.  P.  Gibbons  who,  for  obtaining  the 
therapeutic  effects  of  grindelia,  found  the  borated  infusion  more 
reliable  than  an  alcoholic  preparation. 
Extractum  Hamuli  Fluidum. — Peter  N.  Duff,  Ph.G.,  prepared  four 
fluid  extracts,  using  in  each  case  16  oz  of  hops  grown  in  New  York 
State  in  1889.  The  menstruums  were  I,  alcohol  8  p.,  water  1  p.; 
2,  alcohol  3  p.,  water  1  p. ;  3,  alcohol  2  p.,  water  1  p.,  and  4,  diluted 
alcohol.  The  hop  was  used  in  No.  20  powder,  and  the  fluid  extracts 
prepared  by  percolation  in  the  usual  manner.  On  keeping  the  pre- 
parations for  some  time  at  a  temperature  of  500  to  6o°  F.,  No.  1 
