3H 
Epinephrin  and  its  Compounds. 
Am.  Jour.  Phariii. 
July,  1903. 
Its  composition  was  found  to  be: 
i.  ii. 
C  =  5872  C=5873 
H  =   6-87  H  =  6-84 
N  =  7*12  N  =  7*15 
Analytical  data : 
I.  0*2200  gramme  substance  yielded  0*4737  gramme  C02  and  0*1360  gramme 
H20  ;  therefore,  C  =  58*72  and  H  =  6*87. 
0*3557  gramme  substance  gave  21*8  c.c.  N  collected  over  50  per  cent.  KOH 
at  t  =  210  C.  and  barometer  =  760  mm.  N  =  7*12. 
II.  0*2438  gramme  substance  yielded  0*5250  gramme  C02  and  0*1500  gramme 
H20  ;  therefore,  C  =  58*73  and  H  =  6*84. 
0*3215  gramme  substance  gave  19*8  c.c.  N,  collected  over  50  per  cent.  KOH 
at  210  C.  and  760  mm.  Hg.  N  =  7*15. 
Identical  analytical  results  have  been  obtained  by  purifying  com- 
mercial preparations  known  as  suprarenalin  (Armour  &  Co.)  and 
adrenalin  (Parke,  Davis  &  Co.). 
At  the  time  these  analyses  were  made  I  had  not  yet  employed 
oxalic  and  trichloracetic  acids  conjointly,  as  above  described.  The 
suprarenalin  of  Armour  &  Co.  was  dissolved  in  absolute  alcohol  con- 
taining trichloracetic  acid,  filtered  and  precipitated  by  ammonia.  It 
was  then  dissolved  in  as  little  dilute  oxalic  acid  as  possible,  and 
ammonium  picrate  and  picric  acid  were  added.  This  solution  was 
allowed  to  stand,  and  then  filtered  Irom  a  small  amount  of  a  dark, 
sticky  picrate.  The  active  principle  was  then  precipitated  by  ammo- 
nia and  thoroughly  washed  with  water,  alcohol  and  ether. 
It  was  then  dissolved  in  dilute  hydrochloric  acid  and  crystallized 
with  the  slow  addition  oi  ammonia. 
It  was  now  found  to  have  the  composition 
0  =  58*58  H  =  6*8o  N=7*09  (Dumas). 
Nearly  a  year  ago  I  purchased  large  amounts  of  adrenalin  and 
subjected  it  to  processes  of  fractional  precipitation.    The  extreme 
variations  of  numerous  fractions  in  respect  to  C,  H,  and  N,  ran  from 
C  =56*53  to  58*89 
H=  4*77  to  7*19 
N=  7*59  to  10*65  (Dumas). 
It  would,  however,  be  an  easy  matter  to  obtain  results  exactly 
like  those  above  cited  from  adrenalin,  if  my  present  methods  of 
purification  were  applied  to  this  substance.  Even  simple  reprecipi- 
tation  (four  times)  with  ammonia  from  its  solution  in  acetic  or 
