^Dei'^r^mr'}  Active  Principle  of  Suprarenal  Gland. 
557 
Table  III. 
Legend  the  same  as  for  Table  11.  Sample  No.  368  was  used,  i  milligram 
to  I  c.c. ;  Epinephrine  solution  i  to  100,000  solution. 
Blood 
Blood 
Rise 
pressure 
pressure 
in 
Time. 
Preparation. 
Dose. 
before. 
after. 
millimeti 
1.30 
Epinephrine 
0.6  C.C. 
128 
154 
26 
1-33 
368 
0.6  mg. 
128 
150 
22 
1.38 
Epinephrine 
0.6  cc. 
126 
154 
28 
1.40 
368 
0.7  mg. 
124 
150 
26 
1-43 
Epinephrine 
0.5  c.c. 
124 
150 
26 
1.49 
0.75  c.c. 
132 
164 
32 
1.52 
368 
1.0  mg. 
122 
150 
28 
1.54 
368 
1.0  " 
120 
148 
28 
1.57 
Epinephrine 
0.7  c.c. 
122 
152 
30 
2.01 
368 
0.8  mg. 
126 
146 
20 
From  this  table  it  will  be  noted  that  the  ratios  of  0.5  of  the 
known  to  0.7  of  the  desiccated  gland  solution  and  0.7  to  i.o,  re- 
spectively, gave  like  rises  in  temperature.  One  milligram  of  the  desic- 
cated drug  therefore  contained  the  amount  of  epinephrine  base  in 
0.7  c.c.  of  the  known  solution,  0.007      0.7  per  cent. 
These  two  tables  are  from  one  of  the  final  experiments  after  the 
approximate  values  of  the  unknown  had  been  worked  out. 
Below  is  given  a  table  showing  the  results  obtained  from  the 
various  samples  by  the  physiological  and  the  colorimetric  method  of 
assay. 
Table  IV. 
Per  cent  Active  Principle  by 
Sample  No. 
Colorimetric  Method 
Physiological  Method 
362 
0.6 
1.0 
363 
0.6 
1.2,   I.O,  1.0 
364 
0.6 
1.0 
365 
0.8 
I.I,  I.I 
366 
0.2 
0.3,  0.2 
367 
0.8 
I.I,  I.O,  I.I 
368 
0.4 
0.7 
369 
0.4 
0.7 
370 
less  than  0.03 
0.04 
I  :  1000  solution 
0.03 
0.035 
From  this  table  it  will  be  seen  that  fairly  large  differences  exist 
in  the  two  sets  of  values ;  however,  it  will  be  noted  that  a  close 
parallelism  exists  between  them.    The  results  by  the  physiological 
