124 
The  Pineal  Gland. 
(Am.  Jour.  Pharm. 
(      March,  1915. 
As  a  step  toward  determining  the  metabolic  differences,  quan- 
titative urinalyses  were  made  on  twenty-four-hour  composite  samples 
of  urine  from  the  two  groups.10  With  proper  regard  for  the 
numerous  other  factors  that  might  vitiate  the  results  obtained  from 
urinalyses,  there  is  a  suggestive  difference  in  the  two  urines  as  may 
be  seen  in  the  summary  given  in  Table  III. 
Table  III. 
Summary  of  Analysis  of  Urines. 
Pineal 
Control 
Total  volume  collected  (24  hours)  
187  C,C. 
160  c.c. 
Specific  gravity  (15.5  C.)  
I. Ol6 
1. 019 
Per  cent. 
Per  cent. 
Total  solids  
2.51 
3.O2 
Water  
.9749  > 
96.98 
Total  mineral  matter  
1.21 
1-37 
Total  nitrogen  
0.628 
O.872 
0.018 
0.025 
Phosphoric  acid  (as  P2O5)  
0.065 
O.O43 
0.016 
O.OI8 
0.020 
O.OI8 
Alkalinity  (as  Na2C03)  
0.053 
O.O37 
Chicks. — A  lot  of  fourteen  chicks  was  secured  at  the  age  of  one 
week.  At  so  early  an  age  sex  could  not  be  determined,  and  the  lot 
was  divided  into  test  and  control  groups  without  knowledge  as  to 
grouping  by  sex.  The  test  chicks  were  placed  on  veal  pineal  tissue 
for  one  week,  with  a  resultant  greater  growth  than  controls.  For 
the  next  four  weeks  they  were  fed  pineal  tissue  from  old  cattle, 
without  gaining.  On  being  placed  on  the  original  veal  preparation 
the  test  chicks  again  grew  in  excess  over  controls. 
Dogs. — The  eighteen  dogs  employed  represent  four  litters.  In- 
fection of  these  puppies  with  distemper  interfered  seriously  with  the 
weight  charts  of  these  animals.  So  long  as  infections  could  be  kept 
out  of  the  animal  quarters,  the  test  animal  outgrew  the  controls,  but 
the  wasting  from  infections  interfered  seriously  with  average  results 
over  prolonged  periods.  It  was  in  connection  with  puppies  that  some 
differences  in  intelligence  were  observed.  No  great  import  is  at- 
tached to  these  observations,  but  it  was  noted  that  the  pineal-fed 
dogs  were  about  one  month  ahead  of  the  others  in  their  habits.  They 
were  the  first  to  learn  to  lap  milk,  the  first  to  respond  to  a  call,  the 
first  to  be  able  to  find  their  way  back  to  the  kennel.   When  work  on 
I  am  under  obligations  to  Mr.  Lewis  Davis  for  these  analyses. 
