180  New  Agent  in  Pulmonary  Tuberculosis.  {  AmAp  ™r\<^arm- 
celeration  of  respiration  observed  which  might  in  itself  account  for 
improvement  through  better  aeration  of  the  lungs  (Chart  2). 
In  those  patients  who  improved  there  was  a  noticeable  diminution 
of  toxaemia,  indicated  by  the  less  frequent  occurrence  or  disappear- 
ance of  rigors  and  hyperidrosis. 
The  amount  of  urine  and  the  excretion  of  urea  were  increased. 
The  appetite  was  in  no  instance  impaired,  but  rather  seemed  to  be 
improved. 
Partly  perhaps  from  a  psychological  effect,  but  certainly  also 
because  of  the  relief  of  cough,  sleep  was  more  continuous,  more 
sound,  and  more  refreshing. 
At  no  time,  except  when  an  inferior  quality  of  turpentine  was 
used,  were  there  any  evidences  of  irritation  of  either  the  heart, 
lungs,  or  kidneys. 
The  weight  increased  and  the  improvement,  both  of  the  general 
condition  and  of  the  pulmonary  lesion,  seemed  to  be  as  rapid  and 
satisfactory  as  under  any  other  form  of  treatment,  and  to  compare 
favorably  with  that  obtained  under  sanatorium  care.  Indeed,  it  is 
noticeable  and  interesting  that  all  of  the  patients  who  were  treated 
in  the  city  made  quite  as  rapid  progress  here  as  afterward  in  the 
country,  and  their  improvement  here  was  quite  as  marked  as  that  of 
those  who  began  their  treatment  in  the  country,  or  who  were  under 
sanatorium  care  there  without  treatment.  This  is  true  also  of  those 
patients  who  throughout  their  treatment  have  remained  in  the  city. 
Interruption  of  the  treatment  was  followed  by  a  diminution  of  the 
erythrocytes  (Chart  1). 
Conclusions. — The  researches  and  their  results  above  reported, 
while  preliminary  and  incomplete,  seem  to  justify  the  following 
conclusions : 
1.  Oxypinene,  prepared  by  the  interaction  of  pinene  vapor  and 
dry  ozonized  air,  possesses  the  valuable  properties  of  refined  and 
purified  oil  of  turpentine  (pinene)  minus  its  undesirable  irritating 
properties.  In  other  words,  pinene  is  modified  by  oxidation  so  that 
it  is  no  longer  as  penetrating  as  pinene,  nor  as  quickly  absorbed,  yet 
it  is  capable  of  producing  the  same  beneficial  therapeutic  effects. 
2.  It  has  marked  germicidal  effect,  in  vitro,  upon  M.  pyogenes 
aureus,  B.  anthracis,  B.  typhosus,  B.  coli  communis,  and  B.  subtilis. 
It  also  appears  to  be  germicidal  to  the  tubercle  bacillus  in  sputum. 
No  experimental  work  has  been  done  with  tubercle  in  situ. 
3.  When  inhaled  it  does  not  produce  irritation  of  the  respiratory 
