400         Therapeutics  and  Chemistry  of  Oxypinenes.  {As™ptemberPi9iT' 
added  to  dilute  peroxide  of  hydrogen,  or  if  ozonized  oil  of  turpen- 
tine is  shaken  with  this  lead  salt,  peroxide  of  lead  is  formed.  If, 
however,  in  the  first  case  the  peroxide  of  lead  thus  formed  remains 
in  contact  with  the  peroxide  of  hydrogen,  both  are  reduced,  resulting 
in  water,  protoxide  of  lead,  and  oxygen. 
From  this  Schoenbein  concluded  that  the  oxygen  in  the  peroxide 
of  hydrogen  and  the  lead  salt  exists  in  opposite  condition  of  purity, 
+ 
thus  HoO.O  and  PbO.O,  and  that  by  union  of  these  molecules  or- 
+  - 
dinary  inactive  oxygen,  O.O,  is  formed.    Schoenbein  called  those 
bodies  containing  negatively  active  oxygen  (or  O)  "  ozonides,"  and 
+ 
all  such  bodies  as  peroxide  of  hydrogen  (H20  O),  barium  oxide 
+ 
(BaO.O),  and  all  oxygen  compounds  which  contained  oxygen  in  a 
positively  active  condition,  "  antozonides."  This  form  of  oxygen 
he  called  "  antozone." 
From  this  we  may  draw  the  conclusions,  first,  that  ozone  and  per- 
oxide of  hydrogen  and  ozone  can  not  exist  together — a  fact  which 
was  definitely  proved  by  Schoene  in  1879,1  and,  secondly,  that  ozone 
can  not  be  absorbed  or  held  in  solution  by  water,  but  will  gradually 
oxidize  this  to  peroxide  of  hydrogen,  which  again,  in  contact  with 
oxidizable  substances,  will  liberate  positively  active  oxygen  and  re- 
form water. 
The  importance  of  these  deductions  lies  in  the  fact  that  when  an 
ozonide  such  as  pinene  ozonide  meets  a  moist  surface  such  as  the 
moist  animal  tissue  the  result  must  necessarily  be  the  formation  of 
peroxide  of  hydrogen  and  an  oxy-compound,  containing  molecular 
oxygen,  and  when  the  peroxide  meets  anything  capable  of  being 
oxidized  by  positive  oxygen  it  will  give  up  one  atom  of  positively  ac- 
tive oxygen  and  form  water. 
On  these  reactions  is  the  therapeutic  value  of  pinene  ozonide 
founded,  and  we  may  now  return  to  the  consideration  of  this  com- 
pound, for,  as  was  pointed  out  in  my  previous  article,  turpentine  is 
one  of  the  best  ozone  carriers  known.  This  was  very  forcibly  brought 
out  by  Chas.  W.  Wetherill  in  an  article  which  appeared  in  the  Smith- 
sonian Institution  Report,  1864,  p.  174,  and  following,  where  he — 
besides  the  quotation  in  my  previous  article — also  states :   "  Upon 
1  Annalen,  vol.  196. 
