Am.  Jour.  Pharm 
Septembe 
;rp^™-j  Therapeutics  and  Chemistry  of  Oxypinenes.  405 
ozonizing  preparations  as  local  antiseptics  and  cleansing  agents  are 
freely  admitted.  It  is  abundantly  proved  by  constant  clinical  experi- 
ence and  record." 
In  a  pamphlet  by  Dr.  Cyrus  Edson  "  Hydrogen  Peroxide  in  Con- 
tagious Diseases,"  1893,  he  recommends  the  free  administration  of  hy- 
drogen peroxide,  both  by  the  stomach  and  intestinal  irrigation.  He 
says  :  "  It  is  my  opinion  that  this  treatment  will  prove  to  be  par  excel- 
lence the  treatment  for  cholera  morbus,  dysentery,  typhus  and  typhoid 
fevers.  As  oil  vehicles  may  carry  as  high  as  twenty-five  volumes  per 
cent,  of  ozone,  it  is  obvious  that  they  likewise  may  be  effectually  em- 
ployed in  the  same  diseases." 
Dr.  W.  J.  Morton,  in  an  article  in  the  New  York  Medical  Journal, 
June  23,  1894,  entitled  "Ozone  and  its  Uses  in  Medicine,"  says: 
"  That  oils  absorb  ozone  in  very  large  quantity  and  part  with  it  slowly 
indeed,  requires  no  special  corroboration,  since  it  has  been  well  known 
for  a  long  time.  The  combination  is  not  an  oxidation,  as  one  might 
expect,  but  the  ozone  is  taken  up  by  the  oil  as  03  and  yielded  up  as  03. 
The  oil  preparations  give  up  their  ozone  when  taken  internally,  and 
equally  so  when  applied  to  ulcers,  diphtheritic  membranes,  and  when- 
ever a  wound  dressing  is  required.  It  is  noted  that  ozonized  oils  re- 
lieve pain  more  quickly  than  if  they  did  not  contain  ozone." 
Of  course  we  know  now  that  the  ozone  is  not  given  up  as  03  but 
as  H202,  when  the  ozonide  comes  into  contact  with  moist  animal 
tissues,  but  this  does  not  in  the  least  detract  from  Dr.  Morton's  con- 
clusions, which  strongly  bear  out  the  contention  that  when  pinene 
ozonide  is  decomposed  in  contact  with  animal  tissues  the  intermediary 
oxypinenes  formed  have  a  greater  therapeutic  value  than  oil  of  tur- 
pentine itself. 
Sir  William  A.  Tilden,  in  "  The  Chemical  History  of  the  Ter- 
penes,"  6  states  :  "  A  few  of  the  derivatives  of  turpentine  were  known 
to  chemists  long  before  they  were  able  to  determine  their  composition. 
Nearly  two  hundred  years  ago  terpene  hydrate  was  described,  and  as 
early  as  1803  hydrochloride  was  obtained  by  passing  hydrogen  chlor- 
ide gas  into  turpentine  oil." 
Since  1885  the  number  of  researches  into  the  character  and  re- 
actions of  the  terpenes  has  greatly  increased.  The  most  important 
contributions  to  our  present  advance  state  of  knowledge  of  these 
G  Science  Progress  in  the  Twentieth  Century,  vol.  6,  London,  1912,  pp. 
46-61. 
