520  The  Pharmacy  of  Oxy-pinene.       { ^VeX'/mT" 
This  liquid  was  maintained  at  about  380  C.  One  of  the  coated 
pills  was  suspended  in  the  liquid,  timed,  and  the  effects  observed.  At 
the  end  of  five  minutes  the  coating  was  visibly  attacked ;  after  fifteen 
minutes  had  passed  the  brown  color  of  the  pills  appeared  through  the 
coating  in  spots.  At  the  end  of  half  an  hour  the  coating  could,  by 
agitation,  be  washed  from  the  pill,  and  the  pill  also  was  beginning  to 
disintegrate. 
While  it  is  true  that  the  above  described  liquid  is  not  identical 
with  the  pancreatic  fluid  of  the  intestines,  it  is  reasonable  to  believe 
that  its  digestive  power  is  not  greater  than  the  natural  secretion,  nor 
yet  is  it  more  alkaline,  the  latter  property  being  largely,  if  not 
wholly,  responsible  for  the  action  upon  the  Stearic  Acid.  There- 
fore, assuming  the  premises  to  be  correct,  it  would  follow  that  a 
pill,  so  coated,  could  not  pass  through  the  intestinal  tract  without, 
at  least,  being  denuded  of  its  coating. 
THE  PHARMACY  OF  OXY-PINENE.1 
By  Henry  C.  Blair. 
Oxy-pinene,  or  pinene  ozonide,  is  so  little  known  to  pharmacists 
that  it  may  be  well  first  to  consider  what  is  known  about  its  com- 
position chemically  and  its  use  therapeutically  before  taking  up 
briefly  the  pharmacy  of  this  most  interesting  substance. 
In  May,  191 5,  issue  of  the  American  Journal  of  Pharmacy 
appears  an  article  on  oxy-pinenes  by  J.  Emil  Blomen,  A.M.,  Ph.D. 
He  says :  "  Nowhere  in  Nature  can  be  found  a  more  marvellous 
'  dead  '  organic  substance  than  this  one  (Terebinthina)  which,  like 
a  living  being,  inhales  oxygen  from  the  air  and,  transforming  it,  gives 
it  off  in  another  form." 
We  know  that  the  pinene  is  the  substance  that  "  inhales  "  oxygen- 
forming  oxides  which  are  given  off  as  oxygen.  If,  in  place  of 
oxygen,  ozone  is  placed  in  contact  with  pinene,  under  certain  condi- 
tions it  will  be  "  inhaled  "  and  ozonides  will  be  formed  which  will 
give  off  oxygen  in  a  nascent  form. 
"  When  ozonides  of  pinene  come  in  contact  with  moisture,  they 
are  decomposed,  forming  peroxide  of  hydrogen  and  oxygen  com- 
pounds of  pinene.  On  prolonged  standing  or  by  heat,  intermolecular 
or  auto-oxidation  will  take  place,  resulting  in  the  higher  oxidation 
products  of  pinene,  pinonic  acid,  etc. 
1  Proc.  Penn.  Pharm.  Assoc.,  1915,  p.  319. 
