420  Varieties.  { A£ejH;  f8H^RM" 
forest  plantations  is  clear  gain.  From  the  C.  Pahudiana  planted  out 
in  the  open  ground  since  1863-4  we  have  gathered  about  5000  kilo- 
grammes of  bark."  The  maximum  price  in  1872  sale  was  5s.  id.,  and 
the  minimum  price  in  May,  1873,  was  2s.  The  whole  may  then  re- 
present at  least  £1500  already  saved  from  destruction,  and  I  will  fur- 
ther add  that  this  tree,  "which  has  now  become  historical,"*  is  not 
unlikely  to  improve  much  with  age,  whilst  the  reverse  is  pretty  sure  to 
be  the  case  (owing  to  the  cinchotannic  acid)  with  the  C.  succirubra. — 
Pharm.  Journ.  (London),  July  19,  1873. 
Varieties. 
Trimethylamina  in  Rheumatism. — Dr.  A.  Gubler  reviews  the  reports  of  Dr. 
Dujardin-Beaumetz  on  the  favorable  results  obtained  by  him  with  this  alkaloid, 
which  he  employed  under  the  name  of  propylamina,  and  compares  them 
with  his  own  observations  and  those  of  many  other  French  physicians;  he 
comes  to  the  conclusion  that  there  is  nothing  to  justify  confidence  into  trime- 
thylamina in  painful  articular  rheumatism.  Among  the  cases  cited,  there  are 
many  absolutely  unfavorable,  while  in  others  merely  a  happy  coincidence  can 
be  observed  ;  not  one  furnishes  a  decisive  proof  supporting  the  favorable  opin- 
ion entertained  by  some. — Journ.  de  Pharm.  et  de  Chim.,  1873,  June,  472— 
476. 
The  conclusions  arrived  at  by  Dr.  Gubler  are  fully  supported  by  the  results 
obtained  by  American  physicians  more  than  ten  years  ago.  At  that  time  the 
trimethylamina  employed  was  obtained  from  herring  pickle  purified  in  the  form 
of  hydrochlorate  by  alcohol.  Dr.  Dujardin-Beaumetz  has  used,  in  a  number 
of  cases,  the  alkaloid  prepared  synthetically.  Trymethylamina,  or  as  it  is  still 
called  by  many,  propylamina,  will  probably  hereafter  remain  obsolete  as  a 
remedy  in  rheumatism  ;  whether  the  true  propylamina  deserves  any  better  fate, 
appears,  to  say  the  least,  very  doubtful,  according  to  the  observations  of  Dr. 
Gubler. — Ed.  Am.  Jour.  Pharm. 
*  The  following  is  from  Mr.  Yon  Gorkom's  account  of  the  Pahudiana  :  "This 
sort  of  Cinchona  soon  raised  a  violent  contest.  Miquel  defined  it  as  the  worth- 
less C.  Carabayensis,  and  remained  of  the  same  opinion.  Howard  examined  it 
carefully  and  described  it  as  a  new  kind,  to  which  he  gave  the  name  of  C.  Pa- 
hudiana, in  order  to  do  honor  to  the  statesman  to  whom,  without  contradiction, 
the  paternity  of  the  Cinchona  culture  belongs.  The  value  of  this  C.  Pahudiana 
was  so  strongly  called  in  question-,  that  the  Indian  Government,  moved  by  the 
"higher  authorities,  forbade  by  a  decree  of  11th  tSept.,  1862,  its  further  extension." 
[It  increased  notwithstanding  from  324,343  in  1862  to  909,155  in  1866. J  "  But 
whatever  may  be  said  of  this  now  historical  plant,  it  has  shown  that  it  can  be 
useful  in  Pharmacy,  and  that  its  product  can  be  sold  for  a  considerable  price 
in  Europe.    In  alkaloidal  contents  it  stands  certainly  near  our  other  barks.'' 
