Am.  Jour.  Pharm. 
April,  1898. 
}    Recent  Literature  Relating  to  Pharmacy. 
211 
208°  C.  It  produces  general  paralysis  on  frogs,  and  death  through 
paralysis  of  the  heart  muscles ;  on  warm-blooded  animals  it  gives 
rise  to  vomiting,  diarrhoea,  and,  finally,  collapse.  No  special  influ- 
ence is  apparent  on  the  arterial  or  respiratory  organs.  Subcutaneous 
injections  produce  no  irritation.  Sekisanine,  C34H34N209.  or 
C34H36N209,  crystallizes  from  dilute  alcohol  in  long,  colorless,  anhy- 
drous columns,  which  are  odorless  and  tasteless,  melting  at  about 
200°  C.  It  is  scarcely  soluble  in  boiling  water,  sparingly  in  ether, 
chloroform  and  benzol,  readily  in  alcohol.  It  is  only  partially  pre- 
cipitated from  acid  solutions  by  sodium  carbonate  £nd  alkaline  solu- 
tions, being  soluble  in  excess  of  the  latter.  The  platinum  salt  melts 
at  1940  C.  It  gives  no  precipitates  with  the  usual  alkaloid  reagents, 
and  no  fluorescence  with  bromine  water,  or  K2Mn208.  Crystallized 
salts  could  not  be  obtained.  Physiologically  it  is  quite  inactive. — 
Chem.  Zeit.  Rept.,  xxii,  13,  through  Pharmaceutical  Journal,  Febru- 
ary 26,  1898. 
A.  Astruc  has  confirmed  the  view  that  calcium  glycerophosphates 
in  solution  are  alkaline  to  methyl-orange,  and  that  they  may  be 
either  acid  or  alkaline  to  phenolphthalein.  To  determine  the  amount 
of  phosphoric  acid  present,  he  neutralizes  a  known  volume  of 
glycerophosphate  solution  with  sulphuric  or  hydrochloric  acid,  with 
methyl-orange  as  indicator,  then  titrates  the  solution  with  standard 
alkali  and  phenolphthalein.  In  the  equation  representing  the  first 
reaction : 
one  molecule  of  mineral  acid  corresponds  to  two  molecules  of  phos- 
phoric acid,  and  in  the  second 
(P04C3H702)2  '  CaH2  +  2NaOH  =  (P04C3H702)2  '  CaNa2  +  2H20 
or, 
one  molecule  of  phosphoric  anhydride  corresponds  to  two  molecules 
of  soda.  The  quantity  of  phosphorus  pentoxide  in  solution  can 
thus  be  calculated,  the  results  obtained  being  about  0  5  per  cent, 
lower  than  those  obtained  by  calcining  a  known  weight  of  glycero- 
ASSAY  OF  GLYCEROPHOSPHATES. 
j  (PQ4C3H702)2  .  CaH2 
(P04C3H702)2  •  CaH2  \    =  j  P04C3H702Ca 
2NaOH  j   ~~    (  P04C3H702Na 
2H20, 
