336     Volatility  of  Some  of  the  Newer  Remedies.  {Amju<i"isISlarm" 
Before  giving  these  results  I  wish  to  state  that  consultation  of  a 
large  number  of  standard  chemical  publications  and  treatises  on  the 
"Newer  Remedies  "  failed  to  reveal  a  single  record  of  these  sub- 
stances subliming  below  their  melting  points.  In  a  paper  on 
"  Ammonol,"  read  by  Mr.  G.  M.  Beringer,  at  the  Pharmaceutical 
Meeting  of  the  Philadelphia  College  of  Pharmacy,  February  17,  1897, 
and  published  in  the  March  issue  of  the  American  Journal  of 
Pharmacy,  1897,  p.  lS°*  'ls  found  the  following  paragraph:  "  The 
filtered  solution  of  1  gramme  ammonol  in  30  c.c.  of  water,  evapo- 
rated on  the  water-bath,  yielded  a  residue  of  0-222  gramme,  and  on 
prolonged  heating,  minute  micaceous  crystals  separated  and  sublimed 
into  loose  tufts  on  the  surface.  These  crystals  proved  to  be  acetani- 
lid,  showing  that,  as  stated  above,  it  had  been  partly  extracted  by 
the  water,  and  that  it  was  more  or  less  volatile  at  the  temperature 
of  the  water-bath."  This  is  the  only  reference  bearing  on  the  sub. 
ject  that  I  was  able  to  find. 
My  knowledge,  two  years  ago,  of  the  volatility  of  the  previously 
mentioned  substances  may  be  summed  up  as  follows  : 
Exalgin  and  acetanilid  volatilize  between  _}.oc  and  500  C;  methace- 
tin  and  phenacetin  volatilize  at  ioo°  C. 
In  the  second  attempt  to  finish  the  experiments,  about  a  year 
ago,  I  noticed  the  sublimation  of  exalgin  between  30:  and  40°  C. 
These  experiments  were  made  by  taking  sections  of  glass  tubing, 
%  inch  in  diameter  and  about  6  inches  in  length,  closing  them  at 
one  end  and  introducing  sufficient  of  the  remedies  to  make  a 
column  1  inch  long ;  after  removing  the  adhering  powder  above  the 
column  and  putting  in  a  small  plug  of  cotton  so  as  to  rest  lightly 
upon  the  powder,  the  tubes  were  arranged  in  a  cork,  with  a  ther- 
mometer occupying  the  central  position,  so  that  the  lower  end  of 
the  tubes  and  the  thermometer  bulb  were  in  the  same  plane,  and 
the  powders  in  the  tubes  wholly  immersed  in  a  tin-can,  which  con- 
stituted an  improvised  air-bath.  The  heat  was  so  regulated  that 
the  maximum  and  minimum  temperatures  did  not  differ  by  more 
than  ioc  C.  during  the  experiment  ;  thus,  in  heating  to  30c-40~  C, 
the  object  was  an  exposure  to  35 0  C,  although  change  in  pressure 
of  the  gas-supply  might  cause  variation  of  several  degrees  either 
way.  The  heat  was  maintained  for  two  days  and  then  increased 
10°  C;  the  tubes  were  frequently  examined  during  this  time  for  the 
appearance  of  sublimates  ;  the  first  proof  of  a  sublimate  was  ob- 
