Am.  Jour.  Pharnj.  \ 
November,  1898.  / 
Deodorized  Tincture  of  Opium. 
557 
of  the  acetone- washed  opium  No.  4,  and  of  deodorized  tincture  made 
from  it,  are  submitted. 
Experiment  No.  8. — 100  grammes  of  No.  40  opium  assaying  16 
per  cent.,  washed  with  methyl  acetate,  freshly  redistilled,  of  sp.  gr. 
0-9268  @  1 50  C.  gave  77-5  grammes  of  residue  assaying  19-6  per 
cent.,  instead  of  the  20*64  per  cent,  it  would  have  assayed  if  no  loss 
had  occurred.  The  methyl  acetate  odor  persistently  adhered  to 
the  residue,  and  after  several  months'  standing  is  apparent  in  the 
deodorized  tincture  made  from  it.  Sample  of  the  methyl  acetate 
washings,  the  residual  opium  and  deodorized  tincture  made  from  it, 
are  submitted,  marked  and  numbered  5.  The  various  morphine 
residues  obtained  in  the  assays  are  submitted  for  comparison. 
A.  — The  ether  washings  from  100  grammes  of  No.  40  opium, 
Experiment  No.  4,  evaporated  to  dryness,  the  residue  extracted 
with  water  and  submitted  to  morphine  assay,  gave  0-0155  gramme. 
The  water-washed  residue  washed  with  2  per  cent,  sulphuric  acid, 
the  acid  washings  neutralized  with  ammonia  and  washed  out  with 
ether-chloroform,  gave  4-425  grammes  of  alkaloids  testing  for  nar- 
cotine. 
B.  — The  ether  washings  from  100  grammes  of  No.  80  opium, 
Experiment  No.  5,  treated  in  the  same  way  as  A,  gave  0-0145 
gramme  of  morphine  and  4-435  grammes  of  alkaloids  (narcotine, 
etc.). 
C.  — The  acetone  washings  from  100  grammes  of  No.  40  opium, 
Experiment  No.  7,  treated  in  the  same  way  as  A,  gave  0.580  gramme 
of  morphine  and  4-860  grammes  of  alkaloids  (narcotine,  etc.). 
D.  — The  methyl  acetate  washings  from  100  grammes  of  No.  40 
opium,  Experiment  No.  8,  treated  in  the  same  way  as  A,  gave  0-080 
morphine  and  5-160  of  alkaloids  (narcotine,  etc.). 
COMPARISON. 
Lots  of  100  grammes  of  No.  40  opium  assaying  16-1  per  cent, 
morphine,  washed  respectively  with  1400  c.c.  of  benzinum,  ether, 
acetone  and  methyl  acetate,  gave  the  following  results; 
Methyl 
Benzine.    Ether.    Acetone.  Acetate. 
Weight  of  extracted  and  dried  opium  .     91-00    80*500    74*  77'5o 
"      "  morphine  in      "        "       .     15-05    14-580    14-310  15*19 
"      "         "        u  washings  .  .  .     none       -015       -580  -08 
f<      "  narcotine,  etc.,  in  washings  .        -iS     4*425     4-860  5*16 
