ON CALISAYA EXTRACT. 
15 
them an increase of efficacy. The pure drug has in ancient 
times been called, to distinguish it, " the purgative," and 
more recently " one of the pillars of physic," titles which in 
our day and our own city, may properly be changed to the 
opprobium of pharmacy. 
ART. II.— ON CALISAYA EXTRACT. 
By Charles Ellis. 
The object of this notice is to induce an examination and 
trial of a preparation from the Calisaya Bark, which may 
perhaps be found to be a valuable addition to the Ust of 
medicinal agents. 
The residuary product left after the crystallization of sul- 
phate of quinia, known by the name of impure sulphate 
of quinia, extract of quinia, and precipitated extract of 
bark, has long been employed in this country as a remedy in 
intermittent fevers. It is analogous to chinoidine and contains 
amorphous quinine, an interesting article upon which, from 
the pen of Baron Liebig, was published in Vol. 18, No. 3, 
of the American Journal of Pharmacy. According to this 
writer, the chief constituent of chinoidine bears the same re- 
lation to quinia that uncrystalline sugar does to crystalline, 
in fact that it is amorphous quinine. These facts are suf- 
ficient to show that the calisaya bark (Cinchona flava) has 
other constituentSj besides its crystallizable alkaloids, of too 
much importance to be overlooked. 
The article under notice, containing as it does, all the 
quinia and cinchonia in the bark, must necessarily be a more 
valuable preparation, than one from which those important 
