16 
ON CALISAYA EXTRACT. 
vegetable alkalies have been separated by crystallization, so 
far as is usually the case in the manufacture of sulphate of 
quinia. 
The frequent demand for an extract of calisaya bark, 
upon which reliance may be placed when administered in 
small doses, and the preference often given to it by physi- 
cians, over the sulphate of quinia, are suflicient reasons, 
without any claim to novelty, for introducing such a prepara- 
tion through the pages of our Journal. In order to distin- 
guish it from the officinal Extract: Cinchonse^ as well as from 
the residuary product alluded to above, the name of Calisaya 
Extract (Extractum Calisayacum) is proposed. 
The following is the mode of preparing it. 
The Calisaya Bark (Citichona flava) finely bruised two 
pounds, boil in a gallon of water acidulated with f.gss. Acid 
Hydrochloric ; strain and boil the residue in two successive 
portions of water, of oi]e gallon each, with a similar quantity 
of acid. To these decoctions mixed together, add about 
3ij. or a sufficient quantity of lime, previously reduced to 
pov/der by the addition of water. Stir the mixture well, 
and set it aside until precipitation ceases to take place. 
This precipitate being strained off, is to be well washed 
with water, dried and digested in hot alcohol, until all the 
taste has been exhausted; then distil off the alcohol, and 
carefully evaporate the product over a water bath to a 
pilular consistence. 
This extract will contain the quinia, the cinchona, and all 
that can possess any medical value in the bark. It will be 
found to be intensely bitter, and if a selection of the true 
calisaya bark has been made, it is believed that the product 
thus obtained, will prove a very efficient remedy, in doses 
but little larger than those in which the sulphate of quinia 
is usually administered. 
The proximate principles of the bark will remain in this 
preparation, in the state of alkaloids, uncombined with acid 
