2 38 QUININE AND CINCHONINE. 
sulphiiret of antimony be boiled for half an hour, with a 
solution of 22.5 parts of carbonate of soda in 250 parts of 
water, filtered hot, cooled slowly and washed with cold 
boiled water and dried in the dark. 
ART. XLIX.— OBSERVATIONS UPON CRYSTALLIZED A^^D 
, , . AMORPHOUS QUININE AND CINCHONINE. 
■ ' ■ ^ By M. WiNCKLER. 
The results which the author has arrived at are of great 
mterest, especially to pharmacologists, as they enable us to 
form a more accurate opinion of the value of quinoidine as 
a therapeutical agent. Winckler had occasion to observe 
that the crystallized cinchonine was converted into amor- 
phous by the action of an excess of sulphuric acid, and at 
the same time found in the hyposulphite of soda a means 
of separating crystalline from amorphous quinine and cin- 
chonine. According to his experiments, quinoidine con- 
tains amorphous quinine and cinchonine invariable propor- 
tions, according to the duration of the action of the acid in 
the preparation of these alkaloids and the nature of the 
barks. These results confirm, on the one hand, what Lie- 
big first stated respecting the nature of quinoidine ; and on 
the other, besides the discovery of amorphous cinchonine. 
point to those conditions by which, in the preparation of 
these alkaloids, the amorphous state may be avoided. 
Some amorphous cinchonine was 'accidentally formed in 
ihe preparation of the sulphate of cinchonine, by adding a 
rather large quantity of concentrated sulphuric acid at once 
to the hot mixture, and then healing it somewhat strongly. 
