282 
Chloral-  Camphor. 
Am.  Jour.  Pharm. 
June,  1886. 
CHLORAL-CAMPHOR. 
By  Charles  W.  Albright,  Ph.G. 
(Abstract  from  a  Thesis.) 
Chloral-hydrate  and  camphor  were  mixed  in  different  proportions. 
The  mixture  made  with  1  p.  of  the  former  and  7  p.  of  the  latter 
was  slightly  damp  after  seven  days,  but  could  easily  be  rubbed  to 
powder ;  made  with  3  p.  of  camphor,  the  powder  became  granular  in 
a  day;  and  with  2  p.  of  camphor,  it  was  not  only  granular,  but 
showed  also  the  presence  of  a  thick  liquid.  Equal  parts  of  the  two 
compounds  soon  became  liquid ;  but,  with  ah  increase  of  the  chloral- 
hydrate,  a  white  powder  remained  in  the  liquid,  and  when  the  pro- 
portion reached  7  of  chloral-hydrate  to  1  of  camphor,  the  pasty 
opalescent  mass  separated  gradually  a  thick,  oily  liquid. 
The  liquid  obtained  from  equal  parts  of  the  two  compounds,  on 
being  agitated  with  water,  does  not  decrease  in  bulk.  It  distils  slowly 
without  change  and  without  leaving  any  residue  when  heated  in  a 
bath  of  ammonium  chloride;  but,  when  direct  heat  was  applied,  a 
portion  of  the  oily  liquid  distilled  over  unaltered,  and  was  followed 
by  a  white,  camphor-like  sublimate,  which  was  soluble  in  alcohol, 
from  which  solution,  on  the  addition  of  water,  a  thick,  oily  liquid  was 
-  precipitated.  The  yellowish-brown  residue  in  the  retort  gave,  with 
alcohol,  a  colorless  solution,  which  had  an  odor  of  ^a  mixture  of 
chloral,  camphor,  and  cedar,  and,  with  water,  gave  an  oily  precipitate. 
Chloral-camphor  dissolves  in  60  per  cent,  alcohol,  and,  on  the  addition 
of  water,  is  again  deposited  unchanged. 
On  mixing  solutions  of  chloral-hydrate  in  5  p.  of  water,  and  of 
camphor  in  5  alcohol,  the  mixture  remains  clear;  but,  on  the  addi- 
tion of  water,  becomes  turbid,  and,  finally,  deposits  an  oily  liquid, 
like  that  resulting  from  direct  union.  Substituting  chloroform  for 
the  alcohol,  the  mixture  of  the  two  solutions  separates  into  an  aqueous 
and  a  denser  layer,  the  latter,  on  the  spontaneous  evaporation  of  the 
chloroform,  leaving  oily  chloral-camphor. 
On  treating  chloral-camphor  with  glycerin,  and  then  with  water, 
a  white  flocculent  mass  is  obtained,  answering  to  all  the  tests  of  cam- 
phor. On  boiling  a  mixture  of  equal  parrs  of  chloral-camphor, 
glycerin  and  water,  an  upper  layer  is  formed,  which  gelatinizes  on 
cooling  to  an  opaque,  greasy  mass,  which  is  liquefied  by  the  heat  of 
the  hand.    On  boiling  equal  parts  of  glycerin  and  chloral -camphor  in 
