354 
Morphine  Lactate. 
/Am.  Jour.  Pharm. 
X       July,  1886. 
eighteen  hours  the  precipitate  was  collected  on  a  filter,  washed  with 
cold  water,  dried  under  100°  C,  and  weighed  in  clasped  watch  glasses. 
Weight  of  precipitate  =  23"  13  grs.  =  79*70  per  cent.  The  theoreti- 
cal yield  of  morphine  hydrate  from  anhydrous  morphine  lactate  is 
80*80.  This  difference  of  about  1  per  cent,  is  just  what  one  would 
expect  on  account  of  the  loss  in  mother-waters  and  washings.  We 
may  therefore  affirm  from  these  results  that  morphine  lactate  as  crys- 
tallized from  water,  has  the  composition  C17H19N03,  C3H603.  So  far  as 
I  am  aware,  this  is  the  only  salt  of  morphine  which  crystallizes  from 
water  as  an  anhydrate.  It  may  here  be  noted  that  the  dose  of  the 
lactate  is  the  same  as  that  of  the  muriate. 
The  solubility  in  water  and  in  alcohol  was  next  determined.  Por- 
tions of  the  salt  were  digested  in  these  menstrua  at  a  temperature 
slightly  under  60°  F.  for  four  hours,  then  for  half  an  hour  at  60°  F. 
with  frequent  agitation.  The  filtered  solutions  were  then  weighed, 
evaporated  to  dryness,  and  the  residues  taken  as  the  quantity  dissolved. 
(a)  Solubility  in  water. 
100-70  — 11-255 
11*255      — 7'94 
One  part  morphine  lactate  is  soluble  in  8  parts  water  at  60°  F. 
(6)  Solubility  in  85  per  cent,  alcohol. 
111-98  —  1-20 
1T20^===92'31 
One  part  morphine  lactate  is  soluble  in  93  parts  rectified  spirit  at 
60°  F. 
I  have  to  thank  Messrs.  J.  F.  Macfarlan  &  Co.  for  kindly  permit- 
ting me  to  publish  this  note. — Abbey  Hill  Chemical  Works,  Edinburgh. 
— Phar.  Jour,  and  Trans.,  May  15,  p.  958. 
DERIVATIVES  OF  PAPAVERINE. 
By  G.  Goldschmiedt. 
Papaveraldine,  C20H19NO5,  is  obtained  by  gradually  adding  a  2 
per  cent,  solution  of  potassium  permanganate  to  25  gms.  of  papa- 
verine, previously  treated  with  sufficient  sulphuric  acid  to  form  an 
acid  salt  and  dissolved  in  1  litre  of  water.  The  quantity  of  perman- 
ganate required  is  about  50  gms.  The  precipitate  is  washed  with 
water  and  extracted  with  alcohol  several  times.  The  yield  is  over 
50  per  cent,  of  the  theoretical.  It  forms  a  yellowish  crystalline 
powder,  which  melts  at  210°,  is  insoluble  in  water,  readily  soluble 
