Am.  Jour.  Pharm. 
Nov.,  1886. 
Jaborine. 
567 
previously  discovered  antipyretics  being  either  phenols  (carbolic  acid, 
hydrochinon,  resorcin,  salicylic  acid),  or  bases  belonging  to  the  chino- 
lin  series  (chinoline,  kairine,  antipyrine,  thalline,  quinine). — Med. 
Chronicle,  Sept.— Cmtralbl.  f.  Min.  Med.,  Aug.  14,  1886. 
JABORINE. 
By  Hardy  and  Calmels. 
Pure  dry  pilocarpine  does  not  yield  jaborine  when  heated  at  100° 
for  six  hours,  neither  can  this  substance  be  obtained  by  the  action  of 
alcoholic  iodides  on  argento-pilocarpidine.  If,  however,  carefully 
dried  pilocarpine  is  heated  rapidly  to  175°,  kept  at  this  temperature 
for  about  half  an  hour,  and  the  product  extracted  with  water  made 
alkaline  with  baryta,  and  shaken  with  ether,  the  ether  contains  jabo- 
rine, and  the  aqueous  solution  contains  pilocarpidine  and  jaboric  acid. 
Jaborine  separates  from  alcohol  or  ether  in  a  brown  mass,  which 
changes  to  a  brittle,  resinous  solid.  It  is  insoluble  in  water,  but  dis- 
solves readily  in  ether,  and  is  also  soluble  in  jaboric  acid.  From 
solutions  of  the  hydrochloride  it  is  thrown  down  by  potash  as  a  curdy 
precipitate,  which  readily  agglomerates  under  warm  water.  When 
boiled  with  concentrated  aqueous  potash  it  is  converted  into  pilocar- 
pidine. 
Jaborine  hydrochloride  is  extremely  soluble  in  water  and  alcohol. 
When  boiled  with  excess  of  hydrochloric  acid,  it  is  converted  into 
pilocarpidine  hydrochloride.  Solutions  of  jaborine  are  brown  with  a 
greenish  fluorescence,  which  is  not,  completely  removed  by  animal 
charcoal.  An  alcoholic  solution  of  free  jaborine  yields  with  a  limited 
quantity  of  platinic  chloride,  a  dirty-white,  gelatinous  precipitate  of 
the  composition  (C22032N404)2,PtCl4 ;  with  platinic  chloride  in  excess, 
a  yellowish- white  precipitate  of  the  composition  C22H32N404,PtCl4,  and 
with  auric  chloride  a  precipitate  of  the  composition  C22H32N404,2AuCl3. 
In  presence  of  a  slight  excess  of  hydrochloric  acid,  platinic  chloride, 
whether  in  excess  or  otherwise,  precipitates  the  compound 
C22H32N404,H2PtC]  6> 
Jaboric  acid  is  separated  from  pilocarpidine  by  precipitating  with 
excess  of  silver  nitrate,  which  forms  a  curdy  precipitate  of  the  com- 
position C19H24N305Ag,AgN03.  Jaboric  acid  resembles  jaborine  in 
appearance,  but  is  very  soluble  in  water,  and  is  not  removed  from  its 
