46 
A.  O.  A.  C.  Work  on  Drugs. 
(  Am.  Jour.  Pnaim. 
I     January.  1906. 
filter  previously  moistened  with  a  mixture  of  alcohol  (3  parts)  and 
water  (1  part).  The  last  portions  of  the  residue  are  transferred  to 
the  filter  by  using  small  portions  of  the  above  hydro-alcoholic  solu- 
tion. The  filtrate  is  to  be  collected  in  the  tared  evaporating  dish. 
Continue  washing  the  residue  and  filter  by  dropping  the  alcoholic 
solution  on  the  filter  and  the  residue  until  the  filtrate  is  no  longer 
bitter.  Add  33  c.c.  of  water  to  the  contents  of  the  evaporating 
dish  and  evaporate  on  water  bath  to  14  grammes,  then  proceed  as 
directed  by  the  Pharmacopoeia. 
Procure  the  same  data  for  the  morphine  thus  obtained  as  outlined 
under  Method  I. 
METHOD  III.  UNITED  STATES  PHARMACOPCEI A,  EIGHTH  REVISION, 
MODIFIED  BY  DOHME. 
Place  10  grammes  of  the  opium  into  a  flask  provided  with  a  con- 
densing tube  and  heat  with  50  c  c.  of  75  per  cent,  alcohol  for  about 
ten  minutes.  Decant  the  fluid  through  a  filter  into  a  porcelain  dish 
and  extract  the  opium  once  more  with  50  c.c.  of  the  same  alcohol. 
Filter,  put  filter  back  in  the  flask,  heat  the  contents  of  the  flask  with 
30  c.c.  o!  the  alcohol,  filter  again,  and  wash  filter  and  residue  with 
about  20  c.c.  of  the  alcohol. 
The  combined  alcoholic  solutions  are  evaporated  to  a  thin  syrup, 
and  then  water  is  added  until  no  more  resin  is  precipitated.  The 
aqueous  fluid  is  filtered  and  after  thorough  washing  evaporated  to 
about  15  grammes. 
Then  proceed  as  given  under  opium  in  the  United  States  Phar- 
macopoeia. 
Procure  the  same  data  for  the  morphine  obtained  as  outlined  under 
Method  I. 
METHOD  IV. — STEVENS,  WITH  ADDITIONS. 
Run  two  sets  of  duplicates. 
Place  8  grammes  of  opium  in  a  120  c.c.  Erlenmeyer  flask  with  4 
grammes  of  fresh  quicklime  (not  air  slaked)  and  20  c.c.  of  water, 
then  agitate  and  stir  with  a  glass  rod  until  a  uniform  mixture  results. 
Add  38  c.c.  of  water  and  stir  frequently  during  one-half  hour.  Filter 
through  a  dry  filter  10  centimeters  in  diameter  and  transfer  exactly 
30  c.c.  to  a  120  c.c.  flask,  add  8  c.c.  of  alcohol  and  20  c.c.  of  ether, 
mix  well,  then  add   1   gramme  of  ammonium  chlorid,  shake  the 
