246 
Glycerole  of  Lupulin. 
f  Am.  Jour.  Pharm. 
t    June  1, 1871. 
quently  free  from  oxygen.)  Care  must  be  exercised  in  selection  of  the 
sulphate  of  iron  used ;  those  crystals  having  the  least  color  are  to  be 
preferred,  and  those  having  the  least  trace  of  peroxide  or  persulphate 
in  them  to  be  rejected  ;  by  filtration  of  the  solution  the  last  remaining 
portions  are  got  rid  of.  The  carbonate,  when  thrown  upon  the  filter^ 
must  be  kept  covered  to  the  last  moment  with  the  hot  water  and 
syrup,  otherwise  it  will  rapidly  oxidise.  The  whole  operation  must 
be  performed  as  caref  ully  and  rapidly  as  possible,  and  when  finished 
will  be  a  beautiful  and  desirable  preparation. 
The  more  nearly  the  chloride  approaches  to  a  perfectly  pure  proto- 
chloride  the  better  and  longer  it  will  keep.  I  have  a  sample  of  proto- 
chloride,  made  in  hydrogen  from  sulph.  of  iron,  in  the  form  of  a  heavy 
syrup,  composed  of  cane  and  grape  sugars,  which  has  kept  per- 
fectly for  over  one  year,  and  I  use  it  as  circumstances  call  for  it.  It 
can  be  combined  with  any  other  tincture  in  the  same  manner  as  with 
cinchona.  It  has  been  decided  by  a  number  of  physicians  in  my 
neighborhood  that  it  requires  a  relative  smaller  dose  of  protochloride 
than  sesquichloride  of  iron.  Each  tablespoonful  (f^ss)  of  this  elixir 
contains  the  same  amount  of  metallic  iron  as  five  (5)  drops  of  the 
officinal  tincture  of  the  sesquichloride.  I  will  also  state  that  it  is 
necessary  to  add  the  sugar  to  the  tincture  as  fast  as  it  percolates 
through. 
The  sugar  contained  in  the  elixir  prevents  the  oxidation  and  preci- 
pitation of  iron,  and  the  free  HCl  mixed  with  the  elixir  probably 
converts  a  portion  of  the  cane  sugar  into  grape  sugar,  and  also  keeps- 
in  solution  any  small  quantity  of  the  iron,  which  may  pass  into  a 
jjer-basic'  condition. 
I  would  like  to  call  attention  to  the  fact,  that  if  comp.  tinct.  cinch* 
U.  S.  P.  is  percolated  in  same  manner,  and  sugar  added,  it  will  pre- 
vent the  usual  precipitation  which  occurs  in  it  on  standing. 
New  York,  May  6,  1871. 
GLYCEROLE  OF  LUPULIN. 
By  Emmet  Kannal. 
(From  the  Author's  Inaugural  Essay.) 
Take  of  Lupulin  one  troy  ounce. 
Alcohol,  six  fluid  ounces. 
Glycerin,  nine  fluid  ounces. 
Cura9ao  cordial,  one  fluid  ounce. 
