290 
Progress  in  Pharmacy . 
Am.  Jour  Pharni. 
June,  1905. 
Quinine  Glycerophosphate  occurs  in  well-defined  crystalline  needles. 
Carre  finds  that  glycerophosphoric  acid  furnishes  two  salts  of 
quinine — a  basic  and  a  neutral  salt.  The  pure  basic  salt  can  be  ob- 
tained by  mixing  alcoholic  solutions  in  the  proportion  of  I  mole- 
cule of  the  glycerophosphoric  acid  and  2  molecules  of  quinine. 
Operating  with  absolute  alcohol  an  anhydrous  salt  is  obtained,  while 
with  8o  per  cent,  alcohol  a  hydrated  salt  results.  The  salt  is  pre- 
cipitated from  the  alcohol  by  the  addition  of  ether,  and  finally 
crystallized  from  warm  alcohol.  {Chem.  and  Drug.,  September, 
1904,  page  466,  from  Bull.  Soc.  Chem.  de  Parish) 
Rexotan  is  a  new  astringent  prepared  by  Aufrecht  by  the  con- 
densation of  tannic  acid  and  urea  by  means  of  formic  aldehyde.  It 
has  the  chemical  formula  C10H14N2O10.  {Chem.  and  Drug.,  Septem- 
ber, 1904,  page  546.) 
Sodium  Perborate y  NaBOs,  may  be  made  by  dissolving  100 
grammes  of  borax  in  900  c.c.  of  water  with  the  addition  of  285 
grammes  of  sodium  hydrate.  To  this  solution  is  added  1,350  c.c,  of 
a  purified  solution  of  hydrogen  dioxide.  After  about  one  hour  in 
the  cold,  crystals  of  NaB03  begin  to  separate. 
The  dried  perborate  maybe  kept  indefinitely  without  change,  and 
contains  10-3  per  cent,  of  available  oxygen.  At  170  C.  water  will 
dissolve  117  per  cent,  of  the  perborate,  corresponding  to  a  solution 
of  0  26  per  cent,  of  hydrogen  dioxide.  The  solution  of  perborate 
has  an  alkaline  reaction,  due  probably  to  the  partial  decomposition 
of  the  NaB03  to  hydrogen  dioxide  and  sodium  metaborate.  {Chem. 
Zeitg.  Rept.y  1905,  page  99.) 
Stovaine. — Dr.  F.  Zernik  has  submitted  stovaine  to  an  extensive 
critical  study,  and  defines  it  as  a  tertiary  amino  alcohol,  chemically 
the  chlorhydrate  of  benzoyl  ethyl  dimethyl  amino  propanol.  Sto- 
vaine is  readily  soluble  in  water,  alcohol  or  acetic  ether.  It  has 
been  recommended  as  a  substitute  for  cocaine,  used  in  the  same  way 
and  in  about  the  same  doses.    {Apoth.  Zeitg.,  1905,  p.  174.) 
Stovaine,  Untozvard  Effect  of. — Dr.  D.  A.  Sinclair,  at  a  meeting 
of  the  Clinical  Society  of  the  New  York  Polyclinic  School  and  Hos- 
pital, reported  the  use  of  stovaine  in  four  cases  with  very  unsatisfac- 
tory results.  In  his  hands  it  proved  less  efficacious,  in  anaesthetic 
effect,  than  cocaines,  and  gangrene  followed  its  use  in  three  of  the 
patients.  A  2  per  cent,  solution  was  used.  {The  Drug  Circ.y  1905, 
p.  152) 
