588 
Progress  in  Pharmacy. 
/Am.  Jour.  Pharm. 
1  December,  1905. 
Alypin. — A  new  local  anaesthetic,  is  the  hydrochloride  of  tetra 
methyl  diamino  ethyl  dimethyl  benzoyl  carbinol.  Alypin  is  a  crys- 
talline, nonhygroscopic  substance,  melting  at  169°  C,  and  is  readily 
soluble  in  water.  Solutions  of  alypin  are  neutral  and  concentrated 
solutions  may  be  kept  for  a  long  time. 
Alypin  is  said  to  be  a  powerful  local  anaesthetic  and  to  be  readily 
absorbed  by  the  mucous  membrane.  It  is  used  in  from  4  to  5  per 
cent,  solutions,  the  anaesthesia  lasting  from  eight  to  ten  minutes. 
(Apoth.  Zeitg.t  1905,  page  586.) 
Clavin,  an  active  ingredient  of  ergot,  is  said  to  have  a  specific 
action  on  the  uterus  and  to  be  quite  innocuous  otherwise.  It  is 
soluble  in  water,  but  insoluble  in  absolute  alcohol.  It  is  said  to  be 
quite  stable.  Aqueous  solutions,  however,  decompose  on  standing. 
(Phar.  Zeit.,  1905,  page  687.) 
Iothion. — Di-  iodohydroxypropane  is  an  ester  ot  hydriodic  acid 
designed  for  external  use,  in  cases  where  the  internal  administration 
of  iodine  or  of  iodine  compounds  would  be  inapplicable.  {Brit,  and 
Col.  Drug.,  Aug.,  1905,  page  142.) 
Novocain,  a  newly  discovered  local  anaesthetic,  is  said  to  be  the 
monochlorhydrate  of  P.  amino  benzoyl  diethyl  amino  aethenol. 
Novocain  occurs  in  acicular  crystals  that  are  readily  soluble  in  water 
and  also  soluble  in  about  30  parts  of  alcohol.  From  its  solution  in 
water  the  free  base  may  be  precipitated  by  alkaline  hydrates  or  car- 
bonates. The  aqueous  solutions  of  novocain  may  be  sterilized  by 
boiling  and  are  used  subcutaneously  in  from  1  to  2  per  cent,  strength. 
(Phar.  Zeit.y  1905,  page  899.) 
Solurol. — This  is  the  trade  name  for  a  preparation  purporting  to 
be  Thyminic  acid,  a  nuclein  derivative  which  has  the  property  of 
holding  uric  acid  in  solution  and  preventing  its  precipitation. 
Solurol  is  a  brownish-yellow,  slightly  deliquescent,  amorphous 
powder,  freely  soluble  in  cold  water,  faintly  acid  in  reaction  and 
almost  tasteless.  Solurol  may  be  given  internally  as  a  powder,  in 
solution  or  in  the  form  of  compressed  tablets.  It  has  been  given  in 
doses  of  from  02  to  0-5  gramme,  and  is  said  to  be  free  from  any 
accompanying  toxic  or  untoward  symptoms.  (Phar.  Jour.,  July, 
1905,  page  94.) 
Sanoform,  methyl  di-  iodo  salicylate,  a  perfectly  odorless  white 
powder,  is  offered  as  a  substitute  for  iodoform.  The  melting  point 
of  sanoform  is  110-5°  C,  it  can  therefore  be  sterilized  at  100°  C. 
without  decomposing.    (Phar.  Jour.,  Sept.,  1905,  page  449.) 
