374 
Pari  cine  and  Aricine. 
Am.  Jour.  Pharm. 
July, 1879 
With  platinum  chloride  a  solution  of  paricine  in  hydrochloric  or 
acetic  acid  gives  a  yellow  amorphous  precipitate.  This  forms  after 
drying  in  the  air  a  pale-yellow  powder,  having  the  composition  repre- 
sented by  (C16H18N20,HCl)2+PtCl4+4H20.  This  salt  is  anhydrous 
at  ioo°C. 
I.  0*4055  gram  of  this  substance,  dried  first  in  an  exsiccator  and 
then  at  ioo°C,  gave  0.0302  H20  and  upon^  combustion  0*0800  Pt. 
II.  0*6903  gram  dried  at  1300  gave  0*0530  H20  and  upon  combus- 
tion 0*1363  Pt. 
Calculated.  Found. 
I.  II. 
Pt  .  .  19-68  19.72  19-61 
4.H20  .  .  7-26  7-44.  7-67 
Paricine,  as  above  mentioned,  readily  undergoes  change,  leaving  a 
resinous  decomposition  product.  If  such  a  preparation  be  dissolved  in 
acid  and  then  after  treatment  with  a  little  animal  charcoal  precipitated 
with  excess  of  ammonia,  it  is  then  obtained,  as  a  rule,  as  an  earthy 
grey  powder.  The  paricine  exhibited  in  1877  at  Amsterdam,  by  the 
firm  of  Jobst,  of  Stuttgart,  had  been  purified  and  prepared  in  this 
manner.  At  that  time  0*2863  of  this  preparation,  dried  at  ioo°C, 
gave  0*7815  C02  and  0*183  H20,  or  74*44  per  cent.  C  and  7*10  per 
cent.  H  ;  consequently  almost  the  same  figures  which  the  alkaloid  puri- 
fied by  the  above  method  requires. 
As  to  the  occurrence  of  paricine,  I  found  it  first  in  the  bark  of  C 
succirubra  from  Darjeeling,  afterwards  in  almost  all  the  barks  of  this 
cinchona  cultivated  in  the  East  Indies.  According  to  my  observations 
it  is  contained  in  the  .largest  quantity  in  the  bark  of  the  most  slender 
branches.  The  further  downwards  the  bark  is  collected  the  less  of 
this  alkaloid  it  contains.  In  the  root  bark  from  Darjeeling  I  could 
detect  only  traces  of  paricine. 
I  have  besides  found  paricine  in  a  Columbia  bark  and  another  South 
American  cinchona  bark,  which  would  be  placed  between  the  Columbia 
and  Pitayo  barks.  This  second  bark  contains,  besides  amorphous 
alkaloid  and  some  cinchonia  and  cinchonidia,  a  large  quantity  of 
paricine.  , 
Howard  cites  an  opinion  of  Gerhardt,  according  [to  which  paricine 
would  stand  in  the  same  relation^to  aricine  as  quinoidia  does  to  quinia 
and  cinchonia.    This  opinion  rests  upon  some  experiments  made  by 
