Am.  Jour.  Pharm  1 
Sept.,  1879.  j 
Researches  on  Albumin. 
465 
a  well-crystallized  condition,  and  gave  results  on  analysis  agreeing 
accurately  with  the  formula  C6H13N02. 
The  successive  crystaline  deposits,  obtained  by  progressively  concen- 
trating the  solutions  from  which  the  leucin,  etc.,  had  been  partially 
separated,  were  composed  of  amido-valeric  and  amido-butyric  acids, 
together  with  two  new,  definite,  crystallizable  products,  tyroleucin 
C7HuN02(CnH2n_3N02)  and  a  body  corresponding  with  the  formula 
C6H11N02(CnH2u_1N02) ;  the  quantity  of  tyroleucin  obtained  was 
about  60  or  70  grams  from  10  kilograms  of  albumin.  Tyroleucin 
presents  itself  as  a  white  crystalline  deposit  of  chalky  aspect,  possess- 
ing scarcely  any  taste,  but  soluble  in  about  20  parts  of  water  at  150. 
It  melts  and  decomposes  at  240°C,  breaking  up  into  a  white  sublimate 
and  a  volatile  oily  base  having  an  odor  of  raddish  ;  it  leaves  behind  an 
abundant  yellow  vitreous  residue.  The  analysis  of  the  chloroplatinate 
of  the  base  gives  it  the  formula  of  collidin,  C8HnN,  and  of  the  vitre- 
ous residue  the  formula  C14H18N202  ;  the  decomposition  of  tyroleucin 
may  therefore  be  taken  as  proceeding  thus  : 
2(C7H11N02)=C14H18N202+2H20 
2(C7H11N02)=C02+C8H11N+C5H11N02 
Collidin.  Amido-valeric 
acid. 
from  which  one  is  led  to  suppose  tyroleucin  to  be  a  compound  of 
amido-valeric  acid  with  a  body  of  the  formula  C9HnN02,  the  latter 
differing  from  tyrosin  only  by  an  atom  of  oxygen.  This  is  rendered 
more  probable  by  the  fact  that  tyrosin,  when  heated  under  similar 
conditions,  breaks  up  into  C02  and  a  base,  C8HnNO,  which  differs 
from  collidin  only  by  an  atom  of  oxygen. 
Among  the  homologues  of  leucin,  amido-valeiic  and  amido-butyric 
acids  were  met  with  in  quantity,  but  amido-propionic  acid  in  very 
small  proportion  only  ;  its  presence,  however,  was  clearly  and  distinctly 
made  out. 
To  the  compounds  of  the  formula  CnH2a+2N02,  the  author  gives 
the  generic  name  leucins,  and  to  those  of  the  formula  CnH2n_1N02  the 
names  leuceins  (n=6) ;  both  seem  to  be  frequently  produced  by  the 
splitting  up  on  crystallization  of  bodies  of  the  formula  CmH2mN204 
(m=io  or  12) ;  however  by  repeated  fractional  crystallization  the  com- 
29 
