76  Fluid  Extract  of  Yerba  Santa.  {^""■/eb^rim*'"'"' 
In  the  second  formula  a  menstruum  of  2  parts  alcohol  and  1  of 
water  was  used  as  follows  : 
Yerba  santa  in  No.  60  powder   225  gm. 
Alcohol   150  " 
Water   75  " 
To  make  225  cc.  of  the  finished  product. 
The  details  of  the  manufacture  of  this  extract  are  identical  with 
those  of  the  first  formula,  except  that  150  cc.  more  menstruum  were 
added  to  exhaust  the  drug  instead  of  140  cc,  as  in  the  former  case. 
A  comparison  of  the  two  processes  would  seem  to  indicate  a  prefer- 
ence for  the  first  formula. 
The  residue  of  the  first  formula  was  found  to  be  odorless,  tasteless, 
and  almost  colorless,  whilst  that  of  the  second  formula  still  retained 
a  slight  odor  and  taste  of  the  drug,  which  would  indicate  that  it  was 
not  entirely  exhausted,  hence  the  extract  could  not  contain  as  much  of 
the  active  principle  of  the  drug  as  that  made  by  the  first  formula, 
both  processes  being  conducted  with  the  same  care  and  attention. 
The  fluid  extract  made  by  the  first  formula  had  a  peculiar  odor,  a 
dark  olive-green  color,  and  possessed  an  astringent  and  strongly  bitter 
taste,  whilst  that  obtained  by  the  second  formula  had  about  the  same 
odor,  but  it  was  much  lighter  in  color,  and  lacked  a  deal  of  the  astrin- 
gency  and  bitterness  which  was  found  in  the  former. 
The  investigations  seem  to  show  clearly  that  a  menstruum  of  3 
parts  alcohol  and  1  part  water  is  much  better  for  completely  exhaust- 
ing the  active  principles  of  the  drug. 
The  alcohol  which  was  recovered  in  the  process  of  distillation  had  a 
strong  odor  oi  the  drug,  and,  in  order  to  purify  it,  5  grs.  of  permanga- 
nate of  potassium  were  added,  and  the  whole  allowed  to  stand  for 
forty-eight  hours,  after  which  it  was  re-distilled.  This  distillate  was 
converted  into  diluted  alcohol  by  adding  the  required  quantity  of 
water.  By  this  process  a  product  was  obtained  which  had  but  a  faint 
odor  of  the  drug,  and  the  liquid  could  be  used  for  many  purposes. 
Pereirine  bydrochlorate  as  a  substitute  for  quinine  in 
cases  of  malarial  fever  is  highly  recommended  by  Ferreira,  of  Brazil  {Bull,  gm, 
de  therap.;  Med.  Chronicle).  To  a  child,  who  could  not  take  quinine,  had  been 
given  two  doses  of  fifteen  grains  of  the  pereirine  salt,  half  an  hour  apart,  and 
after  a  repetition  of  like  doses,  the  next  day,  rapid  recovery  took  place,  with 
no  further  attacks. 
