276  Notes  on  Some  New  Remedies.  {^'^'/^S^e:S&^'''^' 
An  examination  of  creolin  by  A.  Gawalowski  (ibid.  p.  229)  elicited 
the  following :  It  is  thickish,  clear,  of  a  dark  granate  red  to  chestnut 
brown  color;  has  a  vinous  aromatic  taste  with  a  pungent  soapy  and 
burning  after-tastCj  and  a  tarry  odor;  reaction  neutral;  spec.  grav.  at 
17.5°  C.  1.066  ;  soluble  in  all  proportions  of  absolute  alcohol,  also  in 
95  per  cent,  alcohol,  chloroform,  and  in  ether  and  acetic  ether ;  soluble 
clear  in  1.7  parts  of  70  per  cent,  alcohol  with  more  becoming  turbid ; 
partly  soluble  in  petroleum  benzin,  leaving  a  tarry  black  brown  residue ; 
insoluble  in  wood  spirit,  becoming  flocculent,  then  oily;  with  carbon 
disulphide  forms  a  light  brown  emulsion  and  separates  a  tarry  layer, 
becoming  whitish-yellow  and  oily;  with  water  forms  a  milky  greenish- 
yellow  liquid ;  with  acidulated  w^ater  yields  a  brownish  emulsion  sep- 
arating a  supernatant  fatty  layer;  with  alkaline  water  gives  a  dingy 
yellow  permanent  emulsion,  and  with  glycerin  likewise  an  emulsion 
separating  an  oily  layer. 
Subjected  to  heat  creolin  yielded  a  distillate  at  100°  C.  amounting 
to  45-0  per  cent.;  between  100°  and  147°  C.  26-33  per  cent,  and  left 
tarry  residue  22*90  per  cent,  and  ash  o'77  per  cent.  The  saponifiable 
fat  acids  and  resins  amount  to  0*30  per  cent. ;  resin  readily  soluble  in 
alcohol  (possibly  guaiac)  0*78  per  cent. ;  tar  bases  0*48  per  cent.;  tar 
compounds  combining  with  alkali  61*88  per  cent.  The  ash  contains 
sodium  with  traces  of  potassium.  The  portion  soluble  in  benzin  was 
72'8  per  cent.,  and  had  an  aromatic  naphthalin-like  odor.  Naphtha- 
lin,  fluorescein,  aniline,  toluidin,  phenol  and  picric  acid  were  deter- 
mined qualitatively.  According  to  this  analysis  creolin  consists  mainly 
of  coal  tar,  with  the  addition  of  some  resin  soap,  fat  soap  and  caustic 
soda. 
For  the  internal  administration  of  creolin  the  form  of  mixture  does 
not  appear  to  be  adapted ;  for  on  diffusing  0*05  gm.  of  it  in  25  gm.  of 
water,  and  adding  5  drops  of  this  emulsion  to  60  gm.  of  syrup  of 
marshmallow,  the  syrupy  mixture  still  had  a  very  persistent  tarry  and 
soapy  taste. 
IVaptbol  water  for  purulent  discharges  from  the  nostrils,  is  prepared  by 
Dr.  Ruault  {Arch.  Laryngol)  by  dissolving  /3  naphthol  125  gm.,  in  alcohol  88  gm., 
and  mixing  a  teaspoonful  of  this  solution  with  a  liter  of  lukewarm  water.  TJie 
unpleasant  sensation  produced  by  the  use  of  this  liquid  disappears  in  a  short 
time.  For  intolerant  patients  a  weaker  mixture  may  be  used,  or  a  preliminary^ 
spray  of  cocaine  may  be  employed. 
