^Ai?g.!im''"'"}        Examination  of  Quinine  Salts.  411 
SYSTEMATIC  EXAMINATION  OF  SULPHATE  AND 
HYDROCHLORATE  OF  QUININE. 
By  C.  Hielbtg. 
Translated  from  Pharm.  Ztschr.f.  Russl,  1888,  258,  by  F.  X.  Moerk,  Ph.  G. 
The  examination  of  these  quinine  salts  ' has  caused  quite  a  number 
of  processes  to  be  devised,  but  not  one  of  these  can  be  relied  upon  in 
furnishing  a  positive  answer  regarding  the  purity  of  these  salts.  To 
frame  a  method  which  allowed  the  presence  or  absence  of  the  more 
frequently  occurring  impurities,  such  as  quinidine,  cinchonine  and  cin- 
chonidine  to  be  proven  in  a  simple  and  comparatively  rapid  manner, 
the  majority  of  the  published  processes  were  carried  out  and  their 
merits  and  defects  ascertained ;  as  the  result  the  following  compilation 
has  been  found  to  work  successfully. 
For  Sulphate.  For  Hydrochlorate. 
1  gm.  and  a  solution  of  0-4  gm.  so- 
A.   1  gm.  with  15  cc.  dium  sulphate  in  1  cc.  water,  with 
30  cc. 
distilled  water  are  agitated  for  5  minutes,  and  filtered.  To  the 
filtrate  is  added  0.5  gm.  Rochelle  salt,  agitated  for  5  minutes,  allowed 
to  stand  5  minutes  and  filtered ;  the  precipitate  of  tartrates  is  collected 
on  a  small  filter  and  reserved,  the  filtrate  for  the 
B.  Detection  of  quinidine  and  cinchonine  is  divided  into  two  por- 
tions, one  of  which  is  reserved  ;  to  the  other  add  1  drop  of  water  of 
ammonia,  and  allow  to  stand  for  a  few  moments. 
1.  The  solution  remains  clear ;  absence  of  quinidine  and  cinchonine, 
proceed  E. 
2.  The  solution  becomes  turbid ;  presence  of  quinidine  and  cincho- 
nine or  both  ;  proceed  C. 
C.  Detection  of  Quinidine.  To  the  reserved  portion  (see  B),  add 
0.5  gm.  KI,  shake  for  5  minutes,  allow  to  stand  for  same  time. 
Observe  either 
1.  The  solution  remains  clear,  if  quinidine  is  absent ;  proceed  D. 
2.  The  solution  becomes  turbid  or  deposits  tenacious  resinous  pre- 
cipitate. In  this  case  cinchonine  must  first  be  tested  for  according  to 
D  and  then 
a.  In  absence  of  cinchonine,  the  turbidity  with  KI  indicates  the 
presence  of  quinidine ;  proceed  E. 
b.  In  presence  of  cinchonine,  the  ammoniacal  solution  in  B  is 
