^°'Aug:^'i888^'*"''}  Characters  of  Antipyrin.  413 
than  the  pure  salt,  there  appears  to  exist  a  dependency  between  the 
two  alkaloids. 
Eemarks  referring  to  Quinine  containing  Cinclionidine.  One-half 
per  cent,  of  cinchonidine  is  easily  detected  within  half  an  hour. 
Should  the  per  cent,  of  cinchonidine  be  so  minute  that  a  precipitate 
can  not  be  clearly  distinguished,  absence  of  the  alkaloid  must  be 
decided  upon,  as  the  reaction  is  so  characteristic  that  there  can 
absolutely  be  no  mistake.  With  one  per  cent,  the  reaction  is  more 
decided  ;  with  two  per  cent,  there  appears  a  deposit  in  the  ether. 
Cinchonidine  is  recognized  by  the  capillary  rising  of  the  precipitate 
beyond  the  ethereal  layer,  immediately  after  shaking  the  solution. 
Care  must  be  exercised  that  not  every  slight  turbidity  at  the  line  of 
contact  of  the  two  liquids  be  pronounced  as  cinchonidine ;  only  in 
case  the  precipitate  is  capillarily  attracted  by  the  side  of  the  test  tube 
can  there  be  no  doubt  regarding  its  presence.  If  the  quinine  con- 
tains ten  per  cent,  cinchonidine  there  appears  at  the  line  of  contact 
-of  the  two  liquids  a  white  cretaceous  ring.  Cinchonidine,  in  the 
:abseuce  of  quinine,  is  separated  as  a  white  precipitate  in  the  ethereal 
layer. 
Remarks  referring  to  Quinine  containing  Cinch onine.  One  per 
oent.  cinchonine  is  easily  recognized ;  the  more  cinchonine  present  in 
the  quinine  the  greater  the  precipitate  with  water  of  ammonia. 
When  more  than  five  per  cent,  cinchonine  is  present  there  forms 
on  addition  of  KI  a  turbidity  of  cinchonine  hydriodate,  which  can 
easily  be  mistaken  for  separated  quinidine ;  ten  per  cent,  causes  a 
precipitate  of  a  tenacious  character  similar  to  quinidine  hydriodate. 
CHARACTERS  OF  DIMETHYLOXYCHINIZIIS^* 
[Antipyrin,  Analgesin.'] 
By  F.  Gay  and  H.  Fortune. 
MELTING  POINT. 
The  published  statements  with  regard  to  the  melting  point  of 
antipyrin  are  not  concordant,    Knorr  gives  113°  C.f;  Regnauld 
gives  110°-112°  C.t;  and  others  give  from  110°  to  113°  C.  We 
^From  the  Journal  de  Pharmacie,  June  15,  p.  594.    Reprinted  from  Phar. 
Jour,  and  Trans.,  June  23,  p.  1066. 
fBerichte,  xvi.,  2597;  xvii.,  546,  2032  ;  Pharm.  Jourii.,  [3],  xv.,  341. 
t  "Traits  de  Pharmacie,"  ii.,  964. 
