THE  AMERICAN 
JOURNAL  OF  PHARMACY. 
SEPTEMBER,  1888. 
GRINDELIA  ROBUSTA  AND  GRINDELIA  SQUARROSA. 
By  William  Henry  Clark,  Ph.G. 
From,  an  inaugural  essay. 
Grindelia  robusta  being  officinal,  and  no  thoroagh  investigation 
having  been  made,  it  was  thought  desirable  to  do  so.  An  analysis  was 
made  in  the  chemical  laboratory  of  the  College,  and  under  the  direc- 
tion of  Professor  Henry  Trimble,  to  whom  I  am  indebted  for  many 
valuable  suggestions.  An  analysis  of  Grindelia  squarrosa  was 
also  made  at  the  same  time,  not  only  on  account  of  its  individual 
interest,  but  especially  for  purposes  of  comparison.  The  work,  in 
general,  was  based  on  Dragendorflf's  Method  of  Plant  Analysis. 
DESCRIPTION  OF  THE  DRUGS. 
G.  robusta  and  G.  squarrosa,  as  found  in  the  market,  consist  of  the 
leaves  and  flowering  tops  of  the  herbs.  They  belong  to  the  natural 
order  Compositse,  and  are  found  west  of  the  Rocky  Mountains,  es- 
pecially in  California. 
There  being  some  uncertainty  as  to  the  means  of  distinguishing 
the  two  species,  a  few  of  the  more  important  points  of  difference  may 
be  of  interest. 
The  drugs  from  which  each  analysis  was  made  were  personally 
selected  in  the  crude  state  from  the  large  stock  of  a  reliable  house,  and 
may  be  relied  upon  as  genuine. 
1.  G.  robusta  is,  as  its  name  implies,  a  robust  grower,  with  large 
numerous  leaves ;  while  G.  squarrosa  is  more  attenuated,  the  leaves 
smaller,  and  branches  and  leaves  less  numerous. 
2.  The  color  of  G.  robusta,  as  seen  in  the  market,  is  of  a  greenish 
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