^"'Dec.'i'im""'  }       Properties  and  Uses  of  SozoiodoL  623 
hypertrophic  rhinitis,  etc.;  the  inflammation  of  the  mucous  membrane 
diminished,  and  the  character  of  the  discharge  was  much  improved. 
In  ozoena  the  mercury  and  zinc  salts  were  used  alternately  daily,  with 
much  beneficial  result,  a  momentary  active  secretion  being  caused, 
followed  by  a  complete  disappearance  of  the  foetor.  In  tubular  ulcers 
of  the  larynx  improvement  was  noted ;  in  syphilitic  affections  of  the 
mouth  and  nose  the  mercury  salt  afforded  most  substantial  service, 
gummatous  affections  of  the  velum  and  tongue  being  completely  cured 
by  insuf&ation  of  mercury  sozoiodol  combined  with  slight  internal 
mercurial  treatment.  Internally  the  salts  have  been  experimentally 
used  by  Langgaard,^  who  found  that  on  rabbits  the  sodium  salt  had  no 
toxic  effect  in  doses  of  1  gm.  (15  grs.) ;  it  was  also  found  that  the 
iodine  was  excreted  as  an  organic  compound  by  the  urine  ;  it  may  be 
here  mentioned  that  Cohn^  could  not  find  any  potassium  iodide  in  the 
lacrymal  secretion  during  the  administration  of  sozoiodol  compounds. 
Langgaard  concludes  that  the  bodies  may,  so  far  as  their  iodine  is  con- 
cerned, be  considered  as  non-poisonous,  in  distinction  to  iodoform  and 
iodol. 
Bufalini  (Ann.  de  Chim.  e  di  Farmac,  1888,  May,  p.  308)  has  ad- 
ministered the  drug  to  a  considerable  number  of  cases  of  phthisis.  He 
observed  little  alteration,  though  the  dose  was  as  much  as  1*5  grm.  per 
diem,  and  certainly  no  toxic  symptoms. 
I  have  been  using  sozoiodol  compounds  for  some  time,  and  have  to 
report  most  favorably  on  the  results  obtained  ;  especially  in  rhinopha- 
ryngitis and  rhinitis  is  this  the  case  ;  the  surfaces  clean  under  the  influ- 
ence of  the  drug,  and  show  a  decided  tendency  to  heal.  In  chronic 
purulent  otitis  the  drugs  have  rendered  very  good  service  both  in  solu- 
tions and  in  insufflations  ;  in  ozoena,  too,  I  can  entirely  confirm  the  ob- 
servation of  Dr.  Fritsche. 
With  respect  to  the  doses  of  the  several  salts,  the  sodium  com- 
pound is  used  pure,  or  dissolved  in  water  3  to  10  per  cent.:  gauze  and 
wool  impregnated  with  this  salt  are  now  prepared,  and  are  most  con- 
venient for  wound  dressings.  If  a  prolonged  action  is  wanted,  the  less 
soluble  potassium  salt  is  used,  either  pure  or  mixed  with  talc  or  milk 
sugar,  five  to  ten  per  cent.;  as  ointments,  all  the  salts  are  used  made  up 
with  lanolin  as  base  in  the  strength  of  five  to  ten  per  cent.;  as  pastes 
^Langgaard,  op.  cit. 
^Ueber  die  Wirkung  des  Calomel  bei  gleichzeitiger  Anwendung  einiger  sub- 
fitituirten  Jodpraparate.   Inaugural  dm.,  Berlin,  1888. 
