4Q  Digitalis  Glucosides  and  Allied  Drugs.  fAm-  Jmr  Pl 
January,  1913. 
(Compare  above.)      (Archiv  fur  experimentelle  Pathologie, 
Vol.  3,  p.  22.) 
Digitoic  acid,  C26  H42  Ot,  melts  at  2100  C.  It  is  formed,  together 
•  with  /?-digitogenic  acid,  on  heating  digitogenic  acid  to  1600  C, 
or  by  warming  it  with  solution  of  caustic  potash.  (Edinger, 
Berichte  der  deutschen  chemischen  Gesellschaft  Berlin  1899, 
p.  339. — Kiliani,  Archiv  der  Pharmacie  1899,  p.  466. — Berichte 
der  deutschen  chemischen  Gesellschaft  Berlin  1899,  p.  2201.) 
Digitoxigenin,  C22  H32  04,  is  a  product  of  decomposition  of  digi- 
toxin.  It  is  formed,  together  with  a  sugar,  so-called  digitoxose, 
by  the  treatment  of  digitoxin  with  alcoholic  hydrochloric  acid 
at  ordinary  temperature.  Digitoxigenin  crystallises  in  color- 
less crystals  melting  at  about  2300  C.  (Archiv  der  Pharmazie 
1895,  p.  311  and  1896,  p.  481. — Berichte  der  deutschen 
chemischen  Gesellschaft  Berlin  1899,  p.  2197.) 
Digitoxin  (solubile)  Cloetta,  according  to  Cloetta,  is  an  amorphous 
modification  of  digitoxin,  and  is  only  distinguished  from  the 
latter  by  the  smaller  size  of  its  molecule  and  its  greater 
solubility  in  water.  Kiliani,  however,  is  of  the  opinion  that 
digitoxin  Cloetta  (digalen)  is  identical  with  digitalein. 
(Cloetta,  Munchener  medizinische  Wochenschrift  1904,  p.  1466 
and  1906,  p.  2281. — Kiliani,  ibid.  1907,  p.  886. — Chemisches 
Zentralblatt  1907,  II,  83. — Merck's  Report  1907,  p.  88.) 
Digitoxin,  according  to  Schmiecleberg  and  Kiliani.  is  a  chemically 
uniform  substance,  which  is  present  in  the  leaves  but  not  in  the 
seeds  of  digitalis.  Kiliani  gave  it  the  formula  C;;4  H-t  On. 
(Compare  above.) 
Digitoxin  Kiliani  )         .  , 
.      .    o  1'    •  *  1         >  are  identical  with  uigitoxm. 
Digitoxin  Schmiedeberg  j 
)8-Digitoxin  is  digitoxin  Kiliani  ) 
a-Digitoxin  is  digitoxin  Schmiedeberg   }  both  are  ldentlcaL 
(Archiv  der  Pharmazie  1895,  p.  311  and  1896.  p.  277  and  481.) 
Digitoxin  e  Pharmacopee  franchise  is  essentially  identical  with  digi- 
toxin. The  French  Pharmacopoeia  requires,  inter  alia,  that  the 
preparation  shall  give  a  green  color  when  dissolved  in  con- 
centrated sulphuric  acid,  whereas  commercial  digitoxin  gives 
a  brown  color  on  solution.  It  also  requires  incorrectly  that 
the  preparation  shall  not  dissolve  in  benzol  (benzene).  As  a 
matter  of  fact,  however,  digitoxin  is  soluble  in  benzol  (C6  H6) 
