198 
Liquor  Ferri  Iodidi. 
J  Am.  Jour.  Pharm. 
\       May,  1913. 
Iodine   
Hypophosphorous  Acid  (50  per  cent.) 
884.  Gm. 
85.  Cc. 
140.  Cc. 
100.  Cc. 
(If  30  per  cent,  acid  be  used)  then  use 
Glycerin  
Distilled  Water,  a  sufficient  quantity 
To  make  one  thousand  cubic  centimeters. 
1000.  Cc. 
To  the  Iron,  contained  in  a  flat  bottom  flask,  add  1000  Cc.  of 
Distilled  Water,  then  gradually  add  the  Iodine,  keeping  the  temper- 
ature down  by  setting  the  flask  in  a  vessel  of  cold  water.  When 
the  Iodine  has  all  been  added,  allow  the  mixture  to  stand  for  12 
hours,  then  heat  to  boiling  until  the  clear  liquid  is  of  a  bright  green 
color.  Then  cool  the  solution  and  filter  through  a  double  filter  paper 
and  wash  the  flask  and  iron  residue  with  several  portions  of  Distilled 
Water  and  pass  the  washings  through  the  filter.  Add  the  Glycerin 
to  the  filtered  solution  and  rapidly  evaporate  in  a  porcelain  dish  on 
a  sand  bath  to  about  eight  hundred  and  fifty  cubic  centimeters. 
Allow  the  solution  to  cool  to<  900  C,  then  add  the  Hypophosphorous 
Acid,  mix  thoroughly  and  when  cold  add  sufficient  Distilled  Water 
to  make  one  thousand  cubic  centimeters. 
The  finished  product  should  be  kept  in  small  glass  stoppered 
bottles  entirely  filled.  It  is  an  emerald  green  liquid,  specific  gravity 
about  1.9  (actual  determination  of  product  gave  1.906). 
Syrup  of  Ferrous  Iodide  made  by  diluting  1  volume  of  this 
liquid  with  15  volumes  of  Syrup  (U.  S.  P.)  showed  a  specific 
gravity  of  1.35,  thus  practically  tallying  with  the  U.  S.  P.  state- 
ment for  specific  gravity  of  the  Syrup  of  Iron  Iodide,  and  maintain- 
ing it  of  the  International  Standard  of  5  per  cent,  of  Ferrous  Iodide. 
In  the  above  formula,  the  Hypophosphorous  Acid  is  advisedly 
directed  to  be  added  to  the  concentrated  Iodide  Solution  after  it  has 
been  allowed  to  cool  to  90  0  C.  If  the  Hypophosphorus  Acid  is 
added  to  the  Iron  Iodide  Solution  before  concentration,  it  is  more 
or  less  decomposed.  The  Pharmacopoeia  states  that  Hypophos- 
phorous Acid  begins  to  decompose  between  130-1400  C.  The  de- 
composition appears  to  commence  below  this  temperature,  and  in 
experiments  where  it  was  added  to  the  solution  before  evaporation, 
the  decomposition  was  quite  marked.  If  the  manipulation  be 
changed  and  the  Hypophosphorous  Acid  added  before  concentra- 
tion, then  the  evaporation  must  be  done  on  a  water-bath. 
