304  Ferri,  Quinince  et  Strych.  Phos.      {Am  jS^i^™1' 
changes  that  take  place  in  the  color  and  flavoring  on  keeping. 
Recently,  another  question  has  been  raised,  namely,  if  Quinine  in 
solution  with  Acetic  Acid  is  not  partly  changed  to  Quinotoxin. 
Consequently,  it  seems  desirable  to  adopt  in  the  revision  a  different 
formula. 
The  pharmaceutical  journals  have  presented  a  number  of  pro- 
posed formulas  and  it  has  fallen  to  my  lot  to  try  many  of  these. 
Without  going  into  a  detailed  account  of  the  experiments  or  criti- 
cism of  these  formulas,  I  will  submit  the  improved  formula  which 
I  have  recommended. 
Elixir  Ferri,  Quinine  et  Strychnine  Phosphatum. 
Soluble  Ferric  Phosphate    17-5  gm- 
Potassium  Citrate    5  gm. 
Quinine   8.75  gm. 
Strychnine    0.275  gm- 
Phosphoric  Acid    2  cc. 
Alcohol    200  cc. 
Glycerin   200  cc. 
Compound  Spirit  of  Orange    10  cc. 
Purified  Talc   30  gm. 
Distilled  Water,  a  sufficient  quantity,   
To  make  1000  cc. 
Dissolve  the  Quinine  and  the  Strychnine  in  the  Alcohol  and 
100  cc.  of  Distilled  Water  to  which  has  been  added  the  Phosphoric 
Acid.  Add  to  this  the  Compound  Spirit  of  Orange.  Dissolve  the 
Soluble  Ferric  Phosphate  and  the  Potassium  Citrate  in  100  cc.  of 
warm  Distilled  Water.  To  this  solution  add  the  Glycerine  and 
then  the  alkaloidal  solution  and  sufficient  Distilled  Water  to  make 
the  product  measure  1000  cc.  Mix  the  Purified  Talc  intimately 
with  the  liquid  and  then  filter,  returning  the  first  portion  of  the 
filtrate  until  a  transparent  liquid  is  obtained.  Lastly,  wash  the 
filter  with  a  mixture  of  1  volume  of  Alcohol  and  4  volumes  of 
Water  until  the  filtered  product  measures  1000  cc. 
In  this  formula  the  proportion  of  the  medicinal  ingredients  is 
retained  the  same  as  in  the  present  official  formula,  as  it  was  not 
deemed  desirable  to  make  any  change  in  the  accepted  strength  or 
dosage.  The  use  of  glycerin  as  the  sweetening  ingredient  in  place 
of  sugar  has  proven  very  satisfactory  in  elixirs  containing  iron 
salts  and  corrects  the  tendency  of  such  elixirs  to  change  color. 
The  green  tint  of  the  product  as  at  first  prepared  appears  to 
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