Amju°iri9i3arm'}      Deodorised  Tincture  of  Opium.  305 
undergo  no  marked  change  after  keeping  for  a  year  or  more. 
Instead  of  using  Aromatic  Elixir  as  a  diluent,  the  elixir  is  made 
in  the  process  of  the  manipulation,  the  Compound  Spirit  of  Orange 
being  added,  thus  insuring  the  greatest  amount  of  flavoring  possible. 
The  manipulation  is  an  important  factor  in  obtaining  a  satisfactory 
product  and  a  reversal  of  the.  directions  as  to  mixing  will  promptly 
demonstrate  this. 
DEODORIZED  TINCTURE  OF  OPIUM.1 
By  Joseph  W.  England. 
The  official  Deodorized  Tincture  of  Opium  is  a  solution  of  the 
water-soluble  proximate  principles  of  opium  made  from  granulated 
opium  and  water,  concentrated  by  evaporation  on  a  water  bath, 
washed  with  purified  petroleum  benzin  and  preserved  with  alcohol. 
The  process  eliminates  resin,  caoutchouc,  ligneous  matter,  odorous 
principles,  etc.  The  preparation  is  analogous  to  the  old  McMunn's 
Elixir  of  Opium. 
The  objection  to  the  official  method  of  making  Deodorized 
Tincture  of  Opium  is  that  it  is  tedious  to  carry  out  and  the  product, 
unless  very  carefully  made,  is  apt  to  have  a  benzin-odor. 
Various  improvements  in  the  official  formula,  including  the 
paraffin-method,  have  been  suggested,  but  the  simplest  and  best 
procedure,  in  the  judgment  of  the  writer,  is  to  make  the  preparation 
directly  from  deodorized  opium,  as  advocated  by  the  late  Professor 
John  M.  Maisch  (King's  American  Dispensatory,  1900,  p.  1978). 
This  has  been  done  in  the  laboratory  of  Smith,  Kline  and  French 
Co.,  for  a  number  of  years  and  with  entire  satisfaction. 
The  following  method  is  recommended: 
Deodorized  Opium  (containing  12  to  12.5  per  cent,  of  crystallizable 
morphine)  one  hundred  grammes   100  gms. 
Alcohol,  two  hundred  cubic  centimeters   200  cc. 
Water,  a  sufficient  quantity  to  make  one  thousand  cubic  centimeters .  1000  cc. 
To  one  thousand  cubic  centimetres  of  cool  water,  in  an  evaporat- 
ing dish,  gradually  add  one  hundred  grammes  of  Deodorized 
Opium,  mix  and  heat  on  a  water  bath  for  six  hours;  replacing 
1  Presented  at  the  annual  meeting  of  the  New  Jersey  Pharmaceutical 
Association,  June  11,  1913. 
