306 
Phylacogens. 
J  Am.  Jour.  Pharm. 
\      July,  1913. 
water  lost  by  evaporation.  When  cool,  pour  the  mixture,  as  evenly 
as  possible,  upon  a  wetted,  non-fluted  paper  filter  in  a  funnel, 
returning  the  first  portion  of  the  percolate  until  it  runs  clear. 
Then  percolate  the  residue  on  the  filter  with  water  until  the  per- 
colate passes  colorless  and  is  only  faintly  bitter.  Concentrate 
the  percolates  on  a  water  bath,  until  they  measure  seven  hundred 
cubic  centimetres,  cool,  add  two  hundred  cubic  centimetres  of 
alcohol,  and  filter  through  a  paper  filter. 
Assay  the  final  product  by  the  process  given  under  Tinctura 
Opii  of  the  U.  S.  Pharmacopoeia  and  adjust  the  volume  of  prepara- 
tion, by  the  addition  of  water,  so  that  each  one  hundred  cubic 
centimetres  shall  yield  not  less  than  1.2  nor  more  than  1.25  Gms. 
of  crystallized  morphine.  By  making  the  final  volume  nine 
hundred  cubic  centimetres,  and  assaying,  the  product  can  be  most 
readily  standardized. 
In  the  making  of  Deodorized  Tincture  of  Opium  from  de- 
odorized opium,  boiling  water  has  been  used,  but,  in  the  writer's 
opinion,  the  use  of  cool  water,  and  then  heating  on  a  water  bath, 
is  preferable. 
PHYLACOGENS.1 
General  Description. 
Since  1910  the  interest  of  medical  circles  has  been  excited  by  the 
extraordinary  results  reported  as  following  the  use  of  a  new  form 
of  bacterial  derivative  in  the  treatment  of  acute  and  chronic  in- 
fections, originated  by  Dr.  A.  F.  Schafer,  of  Bakersfield,  California, 
who  first  presented  his  discovery  to  the  profession  through  the 
San  Joaquin  Medical  Society,  at  Fresno,  California,  October,  1910, 
and  later  through  the  San  Francisco  Medical  Society  on  January 
14,  191 1.  Dr.  Schafer's  preliminary  paper  was  published  in  the 
Therapeutic  Gazette,  April  15,  191 1. 
Theory:  The  Views  of  Dr.  Schafer. 
The  principle  upon  which  the  use  of  these  Phylacogens  is 
founded  is,  briefly,  the  theory  of  multiple  infections.    The  prin- 
1  In  response  to  a  request  by  the  editor  of  this  Journal  for  a  brief  article 
giving  a  summary  of  the  nature,  properties  and  uses  of  Phylacogens,  Messrs. 
Parke,  Davis  and  Company  have  sent  a  voluminous  article  of  which  this  is 
an  abstract. 
