Am.  Jour.  Pharm. ) 
July,  1913.  / 
Phylacogens. 
313 
Anaphylaxis. 
Extensive  studies  with  laboratory  animals  were  undertaken  for 
the  purpose  of  determining  whether  anaphylaxis,  or  dangerous 
sensitization  of  animals,  could  be  produced  by  injections  of  these 
Phylacogens.  No  anaphylactic  reactions  (29)  were  observed  in  the 
experiments,  which  were  most  exhaustive. 
Clinical  Testing. 
In  order  to  obtain  an  abundance  of  clinical  evidence  to  sub- 
stantiate or  refute  the  claims  for  the  Phylacogens,  a  series  of 
searching  clinical  tests  was  instituted  in  March,  191 1,  large  quan- 
tities of  the  various  Phylacogens  were  submitted  to  skilled  clini- 
cians, and  these  clinical  tests  are  being  continued  at  the  present 
time.  This  investigation  has  furnished  abundant  evidence  of  the 
therapeutic  value  of  the  Phylacogens. 
With  an  incredulity  amounting  to  suspicion,  and  with  every 
determination  to  be  no  man's  dupe,  a  searching  investigation  was 
begun  of  Dr.  Schafer's  claims  for  his  bacterial  derivatives  (Phy- 
lacogens). A  vast  mass  of  work  has  been  done: — in  the  laboratory, 
on  animals,  in  the  hospitals,  at  the  bedside.  Literally  hundreds  of 
reputable  physicians  have  administered  thousands  of  doses  of  the 
Phylacogens  for  rheumatism,  gonorrhea,  erysipelas,  and  mixed  in- 
fections. A  cool  critical  survey  of  the  clinical  results  has  con- 
vinced us  that  the  Phylacogens  possess  great. therapeutic  power. 
Reports  have  been  received  in  detail  of  six  thousand,  three 
hundred  and  twenty-four  (6324)  cases  of  various  conditions  (from 
March  15,  191 1,  to  May  30,  1913)  treated  with  Phylacogens. 
These  clinical  reports  include  records  from  nine  foreign  countries 
as  follows :  Canada,  England,  Scotland,  Mexico,  Cuba,  South 
Africa,  New  South  Wales,  New  Zealand,  Jamaica,  W.  I.  These 
together  with  the  United  States,  make  ten  countries  where  Phy- 
lacogens have  already  been  tested  clinically.  This  series  includes 
cases  of  all  kinds  without  regard  to  age,  sex,  nationality,  color, 
condition,  environment,  part  of  the  United  States,  Physician  in  at- 
tendance, whether  hospital  or  private  case,  whether  suited  or  un- 
suited  for  treatment.  Of  this  series  of  6324  cases,  5270  are  re- 
ported as  cured,  and  one  thousand  and  fifty-four  (1054)  are 
arbitrarily  recorded  as  failures. 
