122 
Current  Literature. 
/Am.  Jour.  Pharm. 
February,  1919. 
bleeding.  (P.  J.  Hanzlik,  Jour.  Pharmacol,  and  Exp.  Ther.,  v.  12, 
pp.  71-117,  1918.) 
J.  F.  C. 
The  Effects  of  Various  Systemic  Agents  on  Superficial 
Hemorrhage. — The  most  effective  hemostatic  agent  on  superficial 
bleeding  by  systemic  (intravenous)  administration  was  epinephrin; 
tyramin  somewhat  less ;  pituitary  extract  was  variable.  Fatal  doses 
of  ergot  and  digitalis  (one  experiment  each)  also  lessened  and  ar- 
rested, respectively,  the  bleeding.  The  effects  of  the  following  (sys- 
temically)  on  bleeding  are  roughly  parallel  to  the  changes  in  blood 
pressure:  coagulen  (Ciba),  kephalin  (Howell),  thromboplastin 
(Squibb),  horse  serum,  stypticin,  gelatin,  saline,  emetine,  and  possi- 
bly peptone.  Nitrite  and  hydrastis  increased  bleeding  with  a  fall  in 
pressure.  The  results  with  the  thromboplastic  agents  might  be  dif- 
ferent with  prolonged  administration.  (P.  J.  Hanzlik,  Jour.  Phar- 
macol, and  Exp.  Ther.,  v.  12,  pp.  1 19-128,  1918.) 
J.  F.  C. 
Atophan  and  Several  of  Its  Derivatives. — Atophan  is  toxic 
to  cold-blooded  but  not  to  warm-blooded  animals;  it  paralyzes  the 
central  nervous  system  and  the  nerves  of  the  heart  in  frogs.  After 
administration  to  men  the  uric  acid  excretion  was  much  increased, 
the  atophan  being  excreted  as  hydroxyphenylquinolinecarboxylic  acid 
which  will,  itself,  increase  uric  acid  excretion.  (L.  Rotter,  Z.  ex  p. 
Path.  Ther.,  19,  176,  1918;  C.  A.,  12,  2384,  1918.) 
J.  F.  C. 
MEDICAL  AND  PHARMACEUTICAL  NOTES. 
Stannoxyl  in  Staphylococcal  Infections. — In  The  Pre- 
scribe!', June,  p.  in,  reference  was  made  to  the  experience  of  A. 
Compton  in  the  use  of  stannoxyl  (a  mixture  of  tin  and  tin  oxide)  as 
a  remedy  for  the  mixed  infection  of  pulmonary  tuberculosis.  The 
dose  was  there  given  as  one  Gm.  daily.  In  a  later  communication 
(Lancet,  1918,  2,  234,  Aug.  24)  the  same  author  reports  on  the 
use  of  this  substance  in  three  cases  of  broncho-pneumonia.  The 
dose  given  was  four  one-Gm.  tablets  the  first  day,  six  the  second, 
and  eight  per  day  afterwards.  The  pulse  and  temperature  dropped ; 
night  sweats  diminished;,  the  sputum  became  less,  and  the  weight 
gradually  increased.    (The  Prescriber,  October,  1918.) 
