Am.  Jour.  Pharm.  \ 
March,  19 19.  > 
Advances  in  Pharmacy. 
159 
Quinine  sulphate   
Acid  hydrochloric   
Acid  acetic  (99  per  cent.)  . . . 
Sodium  chloride  
Liquor  formaldehyde,  U.  S.  P, 
Thymol   
Alcohol  (90  per  cent.)   
Distilled  water  
q.  s.  1,000.00  mils 
1. 00  gm. 
0.50  mils 
5.00  mils 
17.50  gms. 
1. 00  mil 
0.25  gm. 
15.00  mils 
Dissolve  the  quinine  in  the  acids ;  dissolve  the  sodium  chloride  in 
the  water;  dissolve  the  thymol  in  the  alcohol;  mix  the  first  two  solu- 
tions and  add  to  this  mixture  the  formaldehyde  solution,  and  then 
to  the  combined  solutions  add  the  thymol  solution. 
The  technic  for  the  application  of  this  solution  is  similar  to  that 
used  in  the  treatment  of  wounds  by  the  Carrel-Dakin  solution,  or  it 
may  be  injected  through  the  Carrel  tubes  every  two  hours,  or  more 
frequently,  if  necessary,  to  keep  the  wound  bathed  with  it. 
Its  efficacy  was  pretty  well  tried  out  in  a  series  of  100  badly 
infected  wounds  at  the  American  Red  Cross  Military  Hospital  No. 
5,  many  of  which  were  compound  comminuted  fractures,  which  had 
been  treated  for  from  ten  days  to  two  weeks  or  longer  with  Dakin's 
solution,  and  in  which  the  bacterial  flora  showed  no  signs  of  de- 
crease in  the  great  majority  of  cases.  There  was  a  marked  drop  in 
temperature  and  pulse  in  many  cases  on  changing  from  Dakin's  to 
quinine-formaldehyde  solution,  without  any  operative  procedure. 
Some  wounds  showing  a  count  of  10  to  15  bacteria  per  field  appar- 
ently have  been  rendered  free  from  germs  within  three  days.  That 
is  to  say,  none  have  been  found  in  the  repeated  examination  of 
fifteen  fields  Thirty  consecutive  cases  treated  within  thirty-six  to 
forty-eight  hours  after  receipt  of  injury,  on  whom  preoperative 
smears  were  made  and  the  presence  of  infection  established,  were 
rendered  sterile  within  forty-eight  hours  and  have  continued  to  show 
absence  of  any  bacteria  on  repeated  counts  subsequently,  with  one 
exception. — Annals  of  Surgery,  Philadelphia,  vol.  68,  1918,  467. 
Feeding  Experiments  zuith  Raw  and  Boiled  Carrots. — Any  con- 
tribution that  will  add  to  our  present  scanty  knowledge  of  vitamins 
is  surely  worth-while  recording.  Denton  and  Kohman  feel  that  in 
the  present  food  crisis  a  knowledge  of  the  dietetic  properties  of  root 
vegetables  is  of  prime  importance,  and  especially  so  since  the  use  of 
dehydrated  vegetables  promises  to  come  into  general  vogue.  In 
their  experiments  they  found  that  carrots,  when  properly  reinforced 
