AmAprSr'  i9^rm'  ^  An  Ioduie  Factory  in  Eastern  Siberia.  245 
fives. — Lactophenin  (lactyl-/>-phenetidine)  and  salophen  (salicylic 
ester  of  acetyl-/?-aminophenol)  were  both  estimated  after  hydrolysis 
in  exactly  the  same  manner  as  phenacetin,  lactophenin  giving  99.3 
per  cent,  and  salophen  100.4  Per  cent.,  after  adding  the  correction 
previously  mentioned. 
Analysis  of  Photographic  Developers. — In  addition  to  the  medi- 
cinal substances  already  mentioned,  there  are  severel  />-aminophenol 
derivatives  largely  used  in  photography  as  developers,  which  may  be 
estimated  in  the  same  manner.  For  instance,  in  a  developer  of  the 
rhodinal  type,  the  proportion  of  />-aminophenol  may  be  quickly 
found  by  direct  treatment  of  the  acidified  solution,  the  sulphite 
present  being  oxidized  by  the  excess  of  chlorine  added. 
In  the  case  of  metol  (methyl-/>-aminophenol  sulphate)  it  is  in- 
teresting to  note  that,  owing  to  the  presence  of  the  methyl  group  in 
the  amino-group,  no  chlorination  of  the  latter  takes  place,  although 
a  quinone  derivative  is  formed.    The  reaction  is  probably 
OH  •  C6H4  •  NH  •  CH,  +  2CI  =  O  :  CRH4 :  N(CH,)  +  2HCI. 
Consequently,  in  the  subsequent  oxidation  of  hydriodic  acid,  only 
two  atoms  of  iodine  are  liberated  per  molecule  instead  of  four,  as 
in  the  case  of  />-aminophenol.  The  reaction  therefore  provides  a 
simple  means  of  distinguishing  between  metol  and  "metol  substi- 
tutes," as  all  the  substitutes  that  I  have  examined  have  proved  to  be 
either  />-aminophenol  or  ^-aminocresol  salts,  none  of  them  showing 
evidence  of  the  presence  of  a  methyl  group  substituted  in  the  amino 
group,  when  tested  by  the  quinone  chlorimine  method. 
I  desire  to  express  by  thanks  to  Messrs.  Boots'  Pure  Drug  Co., 
in  whose  laboratories  the  above  work  was  carried  out. 
AN  IODINE  FACTORY  IN  EASTERN  SIBERIA.1 
By  Dorothy  F.  Findlay,  M.P.S., 
VLADIVOSTOK,   E.  SIBERIA. 
We  came  upon  it  on  the  edge  of  a  beautiful  little  bay,  about  200 
miles  north  of  Vladivostok,  surrounded  by  immense  bush-covered 
hills.  Among  the  vastness  of  the  Siberian  scenery  the  little  iodine 
factory  looked  very  insignificant — a  big  chimney,  a  low  red  brick 
1  Reprinted  from  The  Pharmaceutical  Journal  and  Pharmacist,  January, 
igig. 
