316 
Curren  t  Lit  era  tu  re. 
Am.  Jour.  Pharm. 
May,  1919. 
Potassium  sulphide    50  Gm. 
Water    250  Gm. 
Dissolve  and  incorporate  with 
Soft  paraffin    250  Gm. 
Lanolin   :  .  250  Gm. 
Afterwards  add 
Zinc  oxide    5  Gm. 
Liquid  paraffin    200  Gm. 
{Paris  med.,  May  18,  1918;  through  The  Prescriber,  February, 
1919.) 
Castellani's  Mixture. — This  preparation,  reported  on  by 
Guerrero  et  al.  as  of  value  in  the  treatment  of  yaws,  has  the  follow- 
ing formula : 
Antimon.  tartarat   0.065  Gm. 
Sod.  salicylat   0.65  Gm. 
Potass,  iodid   4.00  Gm. 
Sod.  bicarb     1.00  Gm. 
Aquam  .ad  30.00  Gm. 
This  quantity  is  given  in  one  dose,  diluted  in  4  ounces  (120  Cc.) 
of  water,  thrice  daily,  to  adult  natives,  one  third  or  less  to  children, 
and  half  doses  to  Europeans.  Pharmaceutically  the  mixture  is  not 
elegant:  it  is  cloudy  and  has  a  sediment  of  antimony  oxide.  This, 
however,  disappears  on  dilution,  or  may  be  avoided  by  the  addition 
to  the  formula  of  8  Cc.  of  glycerin.  Castellani's  original  article  is 
abstracted  in  The  Prescriber,  1916,  p.  264.  {Philippine  Jour.  Sci- 
ence, 1918,  13,  191,  July;  through  The  Prescriber,  February,  1919.) 
Dakin's  Solution  :  A  New  Formula. — The  accepted  formula 
for  Dakin's  solution1  consists  of  chlorinated  lime,  sodium  carbonate, 
sodium  bicarbonate  and  water.  The  lime  is  mixed  with  water  and 
allowed  to  settle ;  the  sodium  salts  are  dissolved  separately  in  an- 
other quantity  of  water  and  the  solution  added  to  the  lime  suspen- 
sion ;  the  precipitated  calcium  carbonate  is  allowed  to  settle,  and 
the  clear  fluid  siphoned  off.  Notwithstanding  the  fact  that  in  this 
formula  the  chlorinated  lime  has  first  to  be  titrated  to  ascertain  the 
percentage  of  available  chlorine,  and  the  quantity  of  sodium  salts 
1  See  American  Journal  of  Pharmacy,  1917,  Vol.  89,  pp.  396  and  497. 
