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Pharmacy  of  Tethelin. 
Am.  Jour.  Pharin. 
June,  19 19. 
borate,  sodium  bicarbonate.,  carron  oil,  etc.  It  is  also  not  advisable 
to  employ  it  locally  following  the  use  of  any  of  these  substances  until 
the  wound  has  been  freed  from  them.  Hypodermic  use  of  tethelin 
is  indicated  during  the  period  of  local  use  of  any  of  these  more  or 
less  alkaline  substances. 
By  virtue  of  its  lipoid  nature,  tethelin  possesses  considerable 
iodine-absorption  power.  For  this  reason,  it  is  not  advisable  to 
employ  it  in  admixture  with  dusting  powders,  liquids,  ointments  or 
other  preparations  which  contain  free  iodine  or  which  are  capable 
of  liberating  free  iodine  when  used  on  a  wound.  It  also  is  not 
advisable  to  use  it  locally,  following  the  employment  of  any  of  these 
substances  until  the  wound  has  been  freed  from  them.  The  use  of 
tethelin,  hypodermically,  is  indicated  during  the  period  that  any  of 
these  free-iodine-bearing  or  free-iodine-generating  substances  are 
being  employed  locally. 
Tethelin  in  any  form  must  not  be  permitted  to  come  into  contact 
with  substances  possessing  oxidizing  properties.  Some  such  sub- 
stances are  sodium  hypochlorite,  potassium  permanganate,  ferric 
chloride,  peroxides,  chlorates,  bismuth  subnitrate,  carron  oil,  ozon- 
ized oils,  iodized  oils,  etc.  When  such  substances  are  being  em- 
ployed locally,  it  is  advisable  to  postpone  the  local  use  of  tethelin 
until  the  wound  has  been  freed  from  them.  Hypodermic  use  of 
tethelin  is  indicated  during  the  time  over  which  such  oxidizing  sub- 
stances are  being  employed  locally. 
Summary. 
Tethelin  is  suggested  as  being  the  growth-controlling  principle 
of  the  anterior  lobe  of  the  pituitary  body. 
It  has  been  employed  hypodermically  in  solution  form ;  locally 
in  solution,  as  a  dusting  powder  and  in  ointment  form  and  by  mouth. 
It  partakes  of  the  nature  of  a  lipoid. 
It  is  an  extremely  sensitive  substance,  even  air  and  moisture 
causing  active  decomposition. 
Extemporaneous  preparations  made  under  the  usual  pharma- 
ceutical conditions  should  be  employed  as  soon  after  manufacture 
as  possible  and  not  stocked. 
Tethelin  in  the  dry  form  and  in  solution  form  must  not  be  heated 
above  8o°  C.  - 
Tethelin  in  solution  form  must  not  be  sterilized  by  boiling  in 
the  air. 
