Am  jour.  Pharm. )    Review  of  Advances  in  Phannacx. 
June,  1919.      }  J 
365 
development  of  this  industry.  Analyses  of  bark  are  made  for  which 
a  reasonable  charge  is  made.  A  botanical  research  has  been  under- 
taken on  the  morphology  of  flower  and  fruit  formations  in  cinchona, 
which  is  expected  to  bring  forth  results  of  considerable  value  in 
connection  with  the  production  of  hybrids. 
The  effect  of  humidity  on  the  causation  of  disease  in  cinchona,  is 
receiving  some  attention,  as  is  also  the  question  of  the  loss  of  seed 
in  seed-beds.  This  study  has  been  stimulated  by  the  many  com- 
plaints of  the  quality  of  seed  supplied  by  the  authorities  to  those 
conducting  cinchona  plantations.  These  losses  were  due  to  attacks 
by  mites.  In  questions  of  this  sort  the  services  of  an  entomologist 
are  needed.  The  effect  of  the  temperature  of  drying  on  the  alka- 
loidal  content  of  the  bark  is  a  very  important  one  and  is  receiving 
attention. 
It  is  of  interest  to  know  that  cinchona  plants  are  being  intro- 
duced into  the  Philippine  Islands  from  India.  A  missionary  institu- 
tion at  Sagada,  Island  of  Luzon,  is  the  pioneer  in  this  attempt.  The 
cultivation  of  cinchona  has  never  been  attempted  before  in  the 
Philippines. — Chemist  and  Druggist,  91  (1919),  p.  45  and  70. 
Acetyl-Amido-Ethoxx  Benzene. — To  the  foregoing  the  coined 
name  pertonal  has  been  attached,  which  no  doubt  will  make  it 
popular  with  the  laity  and  tend  to  encourage  self-medication  in  the 
same  manner  that  the  giving  of  the  euphonious  title  "  aspirin  "  to 
acid  acetylsalicylic,  has  proven.  The  action  of  this  combination  has 
been  studied  and  compared  to  acetphenetidm.  It  has  about  one 
half  the  toxicity  of  the  latter  and  as  an  antipyretic  it  produces  similar 
effects  in  doses  about  double  those  of  acetphenetidin.  AVhile 
acetphenetidin  has  a  direct  depressant  action  on  the  heart,  this  organ 
is  actually  stimulated  by  pertonal.  Against  an  antipyretic  ratio  of 
two  parts  of  pertonal  to  one  part  of  acetphenetidin,  the  correspond- 
ing ratio  for  narcotic  action  is  approximately  15  to  1.  It  can  be 
said  that  in  general  the  action  of  pertonal  is  less  abrupt  and  more 
prolonged  than  that  of  acetphenetidin.  It  was  shown  that  both 
drugs  are  excreted  mainly  in  the  urine  in  the  form  of  p.  amidophenol 
and  phenetidin.  It  seems  that  a  larger  amount  of  phenetidin  and 
a  correspondingly  smaller  amount  of  p.  amidophenol  is  set  free  in 
the  tissues  by  pertonal  than  by  acetphenetidin.  Xo  evidence  of  the 
formation  of  methemoglobin  has  been  found  after  the  intake  of 
pertonal,  although  this  change  is  often  noticed  after  the  intake  of 
