474  Chloramine-T  an  Intestinal  Antispetic.     { Am'^S^T'^grm' 
terial  vaccines  prepared  in  oil  do  not  deteriorate  is  also  of  decided 
value  when  mass  vaccination  is  under  consideration. 
A  lipodysentery  vaccine  has  already  been  produced  at  the  Army 
Medical  School,  and  recently  Fennel  prepared  a  lipopneumococcus 
vaccine  which,  because  of  the  simplicity  of  inoculation,  will  perhaps 
supersede  the  method  of  inoculation  recommended  by  Lister. 
An  interesting  application  has  been  made,  too,  by  Bossan  and 
Le  Moignic  with  a  lipotuberculin.  They  find  that  such  vaccines, 
containing  either  the  complete  suspension  of  tubercle  bacilli  or  the 
filtered  product  of  the  dissolved  material,  are  efficient  as  antigens 
and  at  the  same  time  quite  innocuous,  so  far  as  local  and  general 
reactions  are  concerned. 
Of  course,  a  number  of  technical  problems  have  presented  them- 
selves in  the  mass  production  of  these  vaccines — matters  of  dosage 
and  of  the  proper  sterilization  of  oils,  and  the  inclusion  of  efficient 
preservatives  and  antiseptics  (all  of  our  common  agents  are  lipo- 
tropic and  therefore  of  lessened  bactericidal  power  in  an  oil  men- 
struum), and  their  sale  in  interstate  commerce  has  so  far  not  been 
authorized  by  our  government — but  there  seems  little  doubt  that 
within  a  few  years  the  use  of  lipovaccines  will  be  of  great  assistance 
in  prophylactic  inoculation  against  a  number  of  infectious  diseases, 
a  procedure  which  so  far  has  been  delayed  because  of  the  inherent 
toxicity  of  the  available  vaccines. 
CHLORAMINE-T  AS  AN  INTESTINAL  ANTISEPTIC.1 
The  high  antiseptic  power  and  feeble  toxicity  of  chloramine-T 
has  suggested  to  P.  Carnot  and  Th.  Bondouy2  the  possibility  of  its 
use  as  an  intestinal  antiseptic.  They  report  an  elaborate  investiga- 
tion as  to  (a)  its  bactericidal  action,  (&)  its  toxic  action,  (c)  its  re- 
action with  the  digestive  juices,  (d)  the  best  method  for  its  admin- 
istration ;  and  they  report  a  series  of  clinical  researches  on  its  use 
internally. 
Bactericidal  Action. — The  bacilli  of  typhoid  and  paratyphoid  are 
destroyed  in  twenty-four  hours  in  a  concentration  of  1:5,000;  the 
colon  bacillus  forms  no  culture  at  1  :  1,000,  while  weaker  concentra- 
1  Reprinted  from  The  Presenter,  April,  1919. 
2  Paris  Med.,  191 8,  8,  468,  Dec.  7- 
