Am" July1' 19?™'  }     Chloramine-T  an  Intestinal  Antispetic.  475 
tions  are  cultivated  with  difficulty  on  bouillon.  The  solution  has  no 
effect  on  Entamoeba  histolytica. 
Toxic  Action. — This  is  very  slight  indeed,  and  the  drug  may  be 
prescribed  without  fear  in  quite  large  doses  even  for  patients  having 
a  sensitive  digestive  tract. 
Reaction  with  Digestive  Secretions. — In  contact  with  the  saliva, 
chloramine-T  is  partially  decomposed  with  liberation  of  small  quan- 
tities of  chlorine,  but  this  decomposition  is  slow  and  may  be  disre- 
garded. The  gastric  and  duodenal  juices  both  decompose  the  drug 
rapidly  and  completely,  consequently  it  is  necessary  in  administra- 
tion to  protect  the  medicament  from  the  action  of  the  stomach.  The 
action  of  both  gastric  and  pancreatic  juices  is  inhibited  by  chlora- 
mine-T in  a  concentration  of  1 :  500,  but  is  not  affected  by  1 :  2,000. 
Methods  of  Administration. — In  accordance  with  these,  findings 
it  is  necessary  so  to  administer  chloramine-T  as  to  reduce  the  rate 
of  its  absorption  and  prolong  its  contact  with  the  intestinal  contents. 
The  authors  find  that  animal  charcoal  satisfactorily  accomplishes 
this,  cachets  or  tablets  containing  chloramine-T  0.05  Gm.  and 
powdered  animal  charcoal  0.3  Gm.  being  a  suitable  form,  four  such 
cachets  or  tablets  being  given  daily.  Another  suitable  adjuvant  is 
powdered  agar-agar,  this  being  mixed  in  the  same  proportion  as  the 
charcoal. 
Clinical  research  shows  that  in  cases  of  gastric  disturbance 
characterized  by  fetid  stools  and  diarrhoea,  the  administration  of  3 
to  6  grains  produces  marked  relief.  Bacillary  dysentery  was 
quickly  relieved  with  two  doses  of  0.12  Gm.  Good  results  were 
also  obtained  in  several  cases  of  intestinal  toxic  infections,  and  in 
two  cases  of  catarrhal  icterus  deodorization  of  the  stools  was  com- 
plete, but  the  icterus  was  unaffected.  In  cases  of  chronic  enter- 
ocolitis little  result  was  obtained,  and  none  in  cases  of  amoebic 
dysentery.  In  one  case  of  paratyphoid  fever  the  result  was  in- 
conclusive. 
